PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19790146-5 2009 In period 2, the addition of lopinavir/ritonavir to the immunosuppressant regimen enabled a reduction in the dose of immunosuppressants required to maintain trough concentrations within the therapeutic range (to 0.3 mg/day for tacrolimus and 75 mg/day for cyclosporine). Ritonavir 39-48 period circadian regulator 2 Homo sapiens 3-11 23364475-9 2013 Although not statistically significant, a trend was observed towards lower maraviroc, darunavir and ritonavir concentrations in period 2 versus period 1; total maraviroc exposure was 3579 ng h/mL (95% CI: 2983-4294) and 2996 ng h/mL (95% CI: 2374-3782) in periods 1 and 2, respectively, and the GM ratio was 0.84 (95% CI: 0.67-1.05). Ritonavir 100-109 period circadian regulator 2 Homo sapiens 128-136