PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10791920-3 1999 However, with serum-stimulation, the amounts of IPt and PEt at 32 degrees C were less than those at 39 degrees C. Pretreatment with PKC inhibitors, Ro-31-8220 and staurosporine, enhanced the accumulation of IPt but not of PEt at 32 degrees C. The tyrosine phosphorylation of phospholipase Cgamma1 (PLCgamma1) was increased either by serum or by pp60(v-src) reactivation. Inositol Phosphates 207-210 phospholipase C gamma 1 Homo sapiens 298-307 31376383-5 2020 In basal conditions, the majority of the mutations confer PLCgamma1 gain-of-function activity through increased inositol phosphate production and downstream activation of NFkappaB, AP-1 and NFAT transcriptional activity. Inositol Phosphates 112-130 phospholipase C gamma 1 Homo sapiens 58-67 20011604-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We show that FGF-2 activates PLCgamma1 in HUVECs measured by analysis of total inositol phosphates production upon metabolic labelling of cells and intracellular calcium increase. Inositol Phosphates 111-130 phospholipase C gamma 1 Homo sapiens 61-70 30510001-3 2018 One such enzyme, phospholipase-Cgamma1, is responsible for cleavage of a plasma membrane lipid substrate, a phosphoinositide, into two second messengers, diacylglycerol, which activates several enzymes including protein kinase C, and an inositol phosphate, which induces intracellular calcium elevation. Inositol Phosphates 237-255 phospholipase C gamma 1 Homo sapiens 17-38 10720944-7 2000 PLC gamma 1 activity was determined by measuring total inositol phosphates in response to different PDGF isoforms. Inositol Phosphates 55-74 phospholipase C gamma 1 Homo sapiens 0-11 7790382-6 1995 The suppression of PLC-gamma 1 tyrosine phosphorylation was accompanied by a decreased production of water soluble inositol phosphates. Inositol Phosphates 115-134 phospholipase C gamma 1 Homo sapiens 19-30 8906806-8 1996 By contrast, CD2 induces PLCgamma-1 tyrosine phosphorylation as efficiently as CD3, with a correlated inositol phosphate production and intracellular calcium increase, and even a higher production of IL-2. Inositol Phosphates 102-120 phospholipase C gamma 1 Homo sapiens 25-35