PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8964835-3	1996	PGF2 alpha and fluprostenol activated PLC (determined by measuring the formation of inositol phosphates) and increased [Ca2+]i in a concentration-dependent manner.	Inositol Phosphates	84-103	heparan sulfate proteoglycan 2	Homo sapiens	38-41	
21719794-8	2011	In conclusion, the stimulation of GABA(B) receptors in human airway smooth muscle cells rapidly mobilizes intracellular Ca(2+) stores by the synthesis of inositol phosphate via the activation of PLC-beta, which is stimulated by G(betagamma) protein liberated from G(i) proteins coupled to GABA(B) receptors.	Inositol Phosphates	154-172	heparan sulfate proteoglycan 2	Homo sapiens	195-198	
19397907-1	2009	The serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) G protein-coupled receptors signal primarily through G alpha(q) to activate phospholipase C (PLC) and formation of inositol phosphates (IP) and diacylglycerol.	Inositol Phosphates	162-181	heparan sulfate proteoglycan 2	Homo sapiens	140-143	
19397907-1	2009	The serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) G protein-coupled receptors signal primarily through G alpha(q) to activate phospholipase C (PLC) and formation of inositol phosphates (IP) and diacylglycerol.	Inositol Phosphates	183-185	heparan sulfate proteoglycan 2	Homo sapiens	140-143	
11889462-4	2002	PLC activity was determined by measuring the total inositol phosphates.	Inositol Phosphates	51-70	heparan sulfate proteoglycan 2	Homo sapiens	0-3	
16615043-5	2006	Thus, inositol phosphate production may be more efficiently regulated by altering the amount of effectors (PLC-beta1-4) and receptors (M1,3,5 subtypes) than by altering the level of Galphaq/11 subunits.	Inositol Phosphates	6-24	heparan sulfate proteoglycan 2	Homo sapiens	107-110	
14500405-7	2003	Blocking cellular PLC with an inhibitor (U73122) reduced inositol phosphate turnover in all of the HNSCC cell lines examined, and treatment with the PLC inhibitor or antisense oligonucleotides targeting PLCgamma-1 significantly reduced in vitro invasiveness of HNSCC cell lines through Matrigel.	Inositol Phosphates	57-75	heparan sulfate proteoglycan 2	Homo sapiens	18-21	
7590930-7	1995	This reduction in inositol phosphate production could be accounted either to an inhibition of PLC activity or to a modified affinity of phospholipase C for its own substrates, i.e., phosphoinositides, which fatty acid composition has been previously demonstrated to be greatly different in alcoholics in comparison to healthy subjects.	Inositol Phosphates	18-36	heparan sulfate proteoglycan 2	Homo sapiens	94-97	
8256209-4	1993	PLC activity was assayed by liberation of inositol phosphates from the enzymatic hydrolysis of tritiated phosphatidylinositol bisphosphate.	Inositol Phosphates	42-61	heparan sulfate proteoglycan 2	Homo sapiens	0-3	
7689100-2	1993	PAF-stimulated PLC as determined by the increase in inositol phosphate levels.	Inositol Phosphates	52-70	heparan sulfate proteoglycan 2	Homo sapiens	15-18	
2153564-6	1990	Kinetic analysis of EGF receptor down-regulation showed that receptor internalization was rapid enough to account for the transient nature of the inositol phosphate response in PLC/PRF/5 cells.	Inositol Phosphates	146-164	heparan sulfate proteoglycan 2	Homo sapiens	177-180	
2838326-6	1988	Comparison of the inositol phosphate and Ca2+ responses of PLC/PRF/5 cells to responses reported in other cell types indicates that this cell line is a good model for EGF action in liver.	Inositol Phosphates	18-36	heparan sulfate proteoglycan 2	Homo sapiens	59-62