PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29706984-3 2018 Since BuChE inactivates ghrelin, a potent orexigenic hormone, we speculated that rivastigmine improves appetite by inhibiting BuChE-mediated ghrelin inactivation. Ghrelin 24-31 butyrylcholinesterase Homo sapiens 6-11 29706984-3 2018 Since BuChE inactivates ghrelin, a potent orexigenic hormone, we speculated that rivastigmine improves appetite by inhibiting BuChE-mediated ghrelin inactivation. Ghrelin 141-148 butyrylcholinesterase Homo sapiens 6-11 29706984-3 2018 Since BuChE inactivates ghrelin, a potent orexigenic hormone, we speculated that rivastigmine improves appetite by inhibiting BuChE-mediated ghrelin inactivation. Ghrelin 141-148 butyrylcholinesterase Homo sapiens 126-131 26073531-3 2015 Previous studies have relied on inhibitors to identify human butyrylcholinesterase (BChE) as the hydrolase in human plasma that converts ghrelin to desacyl ghrelin. Ghrelin 137-144 butyrylcholinesterase Homo sapiens 61-82 27150892-0 2016 Serum Cholinesterase (Butyrylcholinesterase) May Play a Role in Body Weight Homeostasis via the Inactivation of Ghrelin. Ghrelin 112-119 butyrylcholinesterase Homo sapiens 6-20 27150892-0 2016 Serum Cholinesterase (Butyrylcholinesterase) May Play a Role in Body Weight Homeostasis via the Inactivation of Ghrelin. Ghrelin 112-119 butyrylcholinesterase Homo sapiens 22-43 26922910-0 2016 Unexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of "hunger hormone" ghrelin. Ghrelin 97-104 butyrylcholinesterase Homo sapiens 32-53 26922910-1 2016 Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining. Ghrelin 195-202 butyrylcholinesterase Homo sapiens 142-163 26922910-1 2016 Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining. Ghrelin 195-202 butyrylcholinesterase Homo sapiens 165-169 26922910-1 2016 Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining. Ghrelin 195-202 butyrylcholinesterase Homo sapiens 248-252 26922910-1 2016 Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining. Ghrelin 277-284 butyrylcholinesterase Homo sapiens 142-163 26922910-1 2016 Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining. Ghrelin 277-284 butyrylcholinesterase Homo sapiens 165-169 26922910-1 2016 Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining. Ghrelin 277-284 butyrylcholinesterase Homo sapiens 248-252 26073531-3 2015 Previous studies have relied on inhibitors to identify human butyrylcholinesterase (BChE) as the hydrolase in human plasma that converts ghrelin to desacyl ghrelin. Ghrelin 137-144 butyrylcholinesterase Homo sapiens 84-88 26073531-4 2015 The reaction of BChE with ghrelin is unusual because the rate of hydrolysis is very slow and the substrate is ten times larger than standard BChE substrates. Ghrelin 26-33 butyrylcholinesterase Homo sapiens 16-20 26073531-4 2015 The reaction of BChE with ghrelin is unusual because the rate of hydrolysis is very slow and the substrate is ten times larger than standard BChE substrates. Ghrelin 26-33 butyrylcholinesterase Homo sapiens 141-145 26073531-7 2015 It was found that 5 different preparations of pure human BChE all hydrolyzed ghrelin, including BChE purified from human plasma, from Cohn fraction IV-4, BChE immunopurified by binding to monoclonals mAb2 and B2 18-5, and recombinant human BChE purified from culture medium. Ghrelin 77-84 butyrylcholinesterase Homo sapiens 57-61 26073531-10 2015 A Michaelis-Menten analysis employing these kinetic values together with serum concentrations of ghrelin and BChE demonstrated that BChE could hydrolyze all of the ghrelin in serum in ~1 h. It was concluded that BChE is physiologically relevant for the hydrolysis of ghrelin. Ghrelin 97-104 butyrylcholinesterase Homo sapiens 132-136 26073531-10 2015 A Michaelis-Menten analysis employing these kinetic values together with serum concentrations of ghrelin and BChE demonstrated that BChE could hydrolyze all of the ghrelin in serum in ~1 h. It was concluded that BChE is physiologically relevant for the hydrolysis of ghrelin. Ghrelin 97-104 butyrylcholinesterase Homo sapiens 132-136 26073531-10 2015 A Michaelis-Menten analysis employing these kinetic values together with serum concentrations of ghrelin and BChE demonstrated that BChE could hydrolyze all of the ghrelin in serum in ~1 h. It was concluded that BChE is physiologically relevant for the hydrolysis of ghrelin. Ghrelin 164-171 butyrylcholinesterase Homo sapiens 132-136 26073531-10 2015 A Michaelis-Menten analysis employing these kinetic values together with serum concentrations of ghrelin and BChE demonstrated that BChE could hydrolyze all of the ghrelin in serum in ~1 h. It was concluded that BChE is physiologically relevant for the hydrolysis of ghrelin. Ghrelin 164-171 butyrylcholinesterase Homo sapiens 132-136 26073531-10 2015 A Michaelis-Menten analysis employing these kinetic values together with serum concentrations of ghrelin and BChE demonstrated that BChE could hydrolyze all of the ghrelin in serum in ~1 h. It was concluded that BChE is physiologically relevant for the hydrolysis of ghrelin. Ghrelin 164-171 butyrylcholinesterase Homo sapiens 132-136 26073531-10 2015 A Michaelis-Menten analysis employing these kinetic values together with serum concentrations of ghrelin and BChE demonstrated that BChE could hydrolyze all of the ghrelin in serum in ~1 h. It was concluded that BChE is physiologically relevant for the hydrolysis of ghrelin. Ghrelin 164-171 butyrylcholinesterase Homo sapiens 132-136 19240252-0 2009 Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase. Ghrelin 9-16 butyrylcholinesterase Homo sapiens 140-154 15143862-9 2004 Plasma ghrelin concentrations did not correlate with nutritional parameters except for cholinesterase which was negatively correlated to ghrelin. Ghrelin 137-144 butyrylcholinesterase Homo sapiens 87-101 12482466-4 2003 The fasting plasma ghrelin concentrations in all subjects were negatively correlated with nutritional parameters such as body mass index, percent body fat and serum cholinesterase concentration. Ghrelin 19-26 butyrylcholinesterase Homo sapiens 165-179 33973470-4 2021 The best candidate S06-1011 increased the level of ghrelin, a substrate of BChE, which can function as improving the mental mood appetite. Ghrelin 51-58 butyrylcholinesterase Homo sapiens 75-79 29441654-5 2018 Butyrylcholine esterase is known to degrade the gastric hormone, ghrelin, which regulates appetite; therefore, we considered that rivastigmine might have an effect on appetite. Ghrelin 65-72 butyrylcholinesterase Homo sapiens 0-23 29777378-9 2018 Low active ghrelin ratio-related factors were advanced age (P < 0.01), severe appetite loss (P < 0.01), and decreased cholinesterase (P < 0.01). Ghrelin 11-18 butyrylcholinesterase Homo sapiens 124-138 29777378-12 2018 CONCLUSIONS: Low active ghrelin ratio was related to lack of appetite and low cholinesterase and tended to be related to anorexia grade 2 or higher in patients with treatment-naive advanced pancreatic cancer. Ghrelin 24-31 butyrylcholinesterase Homo sapiens 78-92 29966864-1 2018 Butyrylcholinesterase (BChE) is a plasma enzyme that hydrolyzes ghrelin and bioactive esters, suggesting a role in modulating metabolism. Ghrelin 64-71 butyrylcholinesterase Homo sapiens 0-21 29966864-1 2018 Butyrylcholinesterase (BChE) is a plasma enzyme that hydrolyzes ghrelin and bioactive esters, suggesting a role in modulating metabolism. Ghrelin 64-71 butyrylcholinesterase Homo sapiens 23-27 29441654-10 2018 Negative correlations were detected between percent changes in butyrylcholine esterase activity and active ghrelin (rs = -0.62, P = 0.033) or active/inactive ghrelin ratio (rs = -0.73, P = 0.007). Ghrelin 107-114 butyrylcholinesterase Homo sapiens 63-86