PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33442814-0 2021 Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway. Ghrelin 0-7 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 57-61 33442814-10 2021 Overexpression of Ghrelin inhibited gastric cancer cell proliferation, migration, invasion, and promoted apoptosis by activating the AMPK pathway, while D-[lys3]-GHRP-6 (a GHSR agonist) treatment relieved the effect, promoting tumorigenesis. Ghrelin 18-25 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 133-137 33442814-11 2021 Ghrelin knockdown increased the glucose uptake and lactic acid release, suggesting that Ghrelin elicited an anti-Warburg effect via AMPK pathway to inhibit gastric tumorigenesis. Ghrelin 0-7 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-136 33442814-11 2021 Ghrelin knockdown increased the glucose uptake and lactic acid release, suggesting that Ghrelin elicited an anti-Warburg effect via AMPK pathway to inhibit gastric tumorigenesis. Ghrelin 88-95 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-136 33442814-12 2021 Ghrelin inhibits cell proliferation, migration, and invasion by eliciting an anti-Warburg effect via AMPK signaling pathway in gastric cancer cells. Ghrelin 0-7 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 101-105 18068666-0 2008 Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons. Ghrelin 0-7 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 27-31 23515333-5 2013 We propose that ghrelin provides neuroprotective effects via AMPK (5" adenosine monophosphate-activated protein kinase) activation and enhanced mitophagy (removal of damaged mitochondria) to ultimately enhance mitochondrial bioenergetics. Ghrelin 16-23 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 61-65 22975059-0 2012 Measurement of AMP-activated protein kinase activity and expression in response to ghrelin. Ghrelin 83-90 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 15-43 22975059-2 2012 AMP-activated protein kinase (AMPK), a highly conserved heterotrimeric protein that plays a key role in energy homeostasis, has been shown to mediate many of these metabolic effects of ghrelin. Ghrelin 185-192 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 22975059-2 2012 AMP-activated protein kinase (AMPK), a highly conserved heterotrimeric protein that plays a key role in energy homeostasis, has been shown to mediate many of these metabolic effects of ghrelin. Ghrelin 185-192 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 22975059-3 2012 Ghrelin is shown to stimulate hypothalamic AMPK activity and inhibit liver and adipose tissue AMPK activity. Ghrelin 0-7 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 43-47 22975059-3 2012 Ghrelin is shown to stimulate hypothalamic AMPK activity and inhibit liver and adipose tissue AMPK activity. Ghrelin 0-7 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 94-98 22975059-4 2012 The effects of ghrelin on AMPK activity can be studied using an elegant kinase assay, which involves immunoprecipitating AMPK protein from the tissue of interest followed by quantifying its enzymatic activity using radiolabeled adenosine triphosphate (ATP) in the presence of a suitable substrate. Ghrelin 15-22 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 26-30 22975059-4 2012 The effects of ghrelin on AMPK activity can be studied using an elegant kinase assay, which involves immunoprecipitating AMPK protein from the tissue of interest followed by quantifying its enzymatic activity using radiolabeled adenosine triphosphate (ATP) in the presence of a suitable substrate. Ghrelin 15-22 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 121-125 22975059-7 2012 These methods have been widely used and published for investigating the effects of ghrelin on AMPK activity. Ghrelin 83-90 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 94-98 21576929-3 2011 Leptin and ghrelin-induced changes in hypothalamic AMPK lead to important alterations in hypothalamic fatty acid metabolism. Ghrelin 11-18 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 51-55 19625456-2 2010 AMPK has been shown to mediate the metabolic effects of hormones such as leptin, ghrelin, adiponectin, glucocorticoids and insulin as well as cannabinoids. Ghrelin 81-88 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 18068666-8 2008 Treatment with ghrelin increased phosphorylation of AMPK and ACC. Ghrelin 15-22 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 52-56 18068666-9 2008 An AMPK inhibitor, compound C, suppressed ghrelin-induced [Ca(2+)](i) increases. Ghrelin 42-49 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 3-7 18068666-10 2008 These results demonstrate that ghrelin increases [Ca(2+)](i) via AMPK-mediated signaling in the ARC NPY neurons. Ghrelin 31-38 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 65-69 19304759-5 2009 Calmodulin kinase kinase 2 (CaMKK2) has been identified as an upstream kinase of AMPK and a key mediator in the effect of ghrelin on AMPK activity. Ghrelin 122-129 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 19304759-5 2009 Calmodulin kinase kinase 2 (CaMKK2) has been identified as an upstream kinase of AMPK and a key mediator in the effect of ghrelin on AMPK activity. Ghrelin 122-129 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 133-137 19304759-6 2009 The fatty acid pathway, hypothalamic mitochondrial respiration, and uncoupling protein 2 have been outlined as downstream targets of AMPK and mediators of ghrelin"s appetite stimulating effect. Ghrelin 155-162 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 133-137 18068666-2 2008 The hypothalamic level of AMP-activated protein kinase (AMPK), an intracellular energy sensor, is activated by peripheral and central administration of ghrelin. Ghrelin 152-159 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 26-54 18068666-2 2008 The hypothalamic level of AMP-activated protein kinase (AMPK), an intracellular energy sensor, is activated by peripheral and central administration of ghrelin. Ghrelin 152-159 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 56-60 18068666-3 2008 We examined whether ghrelin regulates AMPK activity in NPY neurons of the ARC. Ghrelin 20-27 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 38-42 15899896-0 2005 Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. Ghrelin 17-24 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 92-120 15899896-4 2005 Here we show that both cannabinoids and ghrelin stimulate AMPK activity in the hypothalamus and the heart, while inhibiting AMPK in liver and adipose tissue. Ghrelin 40-47 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 58-62 15899896-4 2005 Here we show that both cannabinoids and ghrelin stimulate AMPK activity in the hypothalamus and the heart, while inhibiting AMPK in liver and adipose tissue. Ghrelin 40-47 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 124-128 15899896-6 2005 The beneficial effects of ghrelin on heart function, including reduction of myocyte apoptosis, and its effects on lipogenesis and carbohydrate metabolism, can also be explained by its ability to activate AMPK. Ghrelin 26-33 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 204-208 15899896-7 2005 Our data demonstrate that AMPK not only links the orexigenic effects of endocannabinoids and ghrelin in the hypothalamus but also their effects on the metabolism of peripheral tissues. Ghrelin 93-100 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 26-30 14742438-7 2004 By contrast, injection of ghrelin in vivo, which increases food intake, stimulates AMPK activity in the hypothalamus. Ghrelin 26-33 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 83-87