PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30009776-9 2018 Consistently, p53 antagonist PFTalpha counteracted TP-induced p53 overexpression and regulation of Bcl2 family transcription, which improved mitochondrial membrane integrity and prevented apoptosis. pifithrin 29-37 BCL2, apoptosis regulator Rattus norvegicus 99-103 31420372-9 2019 Furthermore, the concentrations of Bax and p53-upregulated modulator of apoptosis were significantly decreased with that of Bcl-2 being significantly increased by administration of SN50, PFT-alpha and ginkgetin. pifithrin 187-196 BCL2, apoptosis regulator Rattus norvegicus 124-129 18775851-6 2008 The functional importance of ERK1/2 and p53 in doxorubicin-induced toxicity was further demonstrated by the specific ERK inhibitor U-0126 and p53 inhibitor pifithrin (PFT)-alpha, which abrogated the changes in Bcl-2 family proteins and cell death produced by doxorubicin. pifithrin 156-165 BCL2, apoptosis regulator Rattus norvegicus 210-215 17487067-0 2007 Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin. pifithrin 148-157 BCL2, apoptosis regulator Rattus norvegicus 57-61