PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25975517-0 2015 The protective effect of eupafolin against TNF-alpha-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. eupafolin 25-34 tumor necrosis factor Mus musculus 43-52 27414646-3 2016 Eupafolin decreased the LPS-induced release of inflammatory mediators (iNOS, COX-2 and NO) and proinflammatory cytokines (IL-6 and TNF-alpha) from the RAW264.7 macrophages. eupafolin 0-9 tumor necrosis factor Mus musculus 131-140 25975517-7 2015 RESULTS: Eupafolin pretreatment reduced the TNF-alpha-induced ICAM-1 expression and also the ERK1/2, JNK, p38, and AKT/PI3K phosphorylation. eupafolin 9-18 tumor necrosis factor Mus musculus 44-53 25975517-9 2015 Eupafolin decreased the TNF-alpha-induced NF-kappaB p65 activation and its nuclear translocation. eupafolin 0-9 tumor necrosis factor Mus musculus 24-33 25975517-10 2015 Furthermore, eupafolin reduced ICAM-1 expression in the lung tissues of TNF-alpha-treated mice. eupafolin 13-22 tumor necrosis factor Mus musculus 72-81 25975517-11 2015 CONCLUSIONS: Eupafolin exerts its anti-inflammatory activity by suppressing the TNF-alpha-induced ICAM-1 expression and subsequent monocyte adhesion via AKT/ERK1/2/JNK phosphorylation and nuclear translocation of NF-kappaB p65. eupafolin 13-22 tumor necrosis factor Mus musculus 80-89