PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Lapatinib	221-230	thymoma viral proto-oncogene 1	Mus musculus	136-139	
30781364-12	2019	Activated c-Met, EGFR, HER2, and protein kinase B (AKT) were significantly suppressed in combination-treated mice tumors, compared to OC or LP monotherapy.	Lapatinib	140-142	thymoma viral proto-oncogene 1	Mus musculus	51-54	
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Lapatinib	232-236	thymoma viral proto-oncogene 1	Mus musculus	136-139	
27197158-7	2016	In HER2-amplified cells, exposure to an mTORC1/2 dual kinase inhibitor decreased Akt-dependent cell survival, including in cells resistant to lapatinib, where cytotoxicity could be restored.	Lapatinib	142-151	thymoma viral proto-oncogene 1	Mus musculus	81-84	
28061785-12	2017	Molecular analysis indicated that lapatinib inhibited phosphorylation and expression of EGFR, erbB-3, erbB-2, Akt1, and Erk1/2 in premalignant mammary tissues.	Lapatinib	34-43	thymoma viral proto-oncogene 1	Mus musculus	110-114	
27293993-7	2016	Furthermore, low-dose lapatinib treatment, starting at the early stages of mammary grand transformation in the MMTV-neu* mouse model, significantly delayed mammary tumor initiation and progression, extended tumor-free survival, which corresponded to effective inhibition of HER2/Akt signaling and downregulation of GLUT4 in vivo.	Lapatinib	22-31	thymoma viral proto-oncogene 1	Mus musculus	279-282	
21482676-2	2011	In a mouse model of mammary carcinoma driven by the polyomavirus middle T (PyVmT) oncogene, the ErbB2 tyrosine kinase inhibitor lapatinib reduced the activation of ErbB3 and Akt as well as tumor cell growth.	Lapatinib	128-137	thymoma viral proto-oncogene 1	Mus musculus	174-177