PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34684576-8 2021 Supplemental ASTX not only increased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and osteogenic transcription factors in the periodontium, but also recovered circulating lymphocytes and endogenous antioxidant enzyme activity in the blood of STZ-injected mice. astaxanthine 13-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 51-94 25924598-9 2015 ATX treatment exerted anti-inflammatory and antioxidant effects by promoting Nrf2 expression and suppressing renal nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation. astaxanthine 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 77-81 25328157-7 2014 There was a significant increase in the hepatic mRNA expression of nuclear factor erythroid 2-related factor 2 and its downstream genes, which are critical for endogenous antioxidant mechanism, in the 0.03% ASTX-supplemented group. astaxanthine 207-211 nuclear factor, erythroid derived 2, like 2 Mus musculus 67-110 34825683-9 2021 Additionally, AST inhibited p38 MAPK and enhanced Nrf2/HO-1 contents in the left paw and DRG, and reversed the pain induced by p38 MAPK agonist and Nrf2 inhibitors. astaxanthine 14-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 51-55 34825683-9 2021 Additionally, AST inhibited p38 MAPK and enhanced Nrf2/HO-1 contents in the left paw and DRG, and reversed the pain induced by p38 MAPK agonist and Nrf2 inhibitors. astaxanthine 14-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 149-153 34684576-0 2021 Astaxanthin Inhibits Diabetes-Triggered Periodontal Destruction, Ameliorates Oxidative Complications in STZ-Injected Mice, and Recovers Nrf2-Dependent Antioxidant System. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 136-140 34684576-8 2021 Supplemental ASTX not only increased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and osteogenic transcription factors in the periodontium, but also recovered circulating lymphocytes and endogenous antioxidant enzyme activity in the blood of STZ-injected mice. astaxanthine 13-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 96-100 32197464-5 2020 More importantly, after ASX pretreatment, compared with the OTA group, serum markers were decreased, epithelial cells appeared normal; the expression of antioxidant enzymes increased significantly, NQO1, HO-1, gamma-GCS and GSH-Px levels increased significantly, and ASX promoted the transfer of NRF2 from the cytoplasm to the nucleus. astaxanthine 24-27 nuclear factor, erythroid derived 2, like 2 Mus musculus 296-300 33129943-0 2020 Astaxanthin protects retinal ganglion cells from acute glaucoma via the Nrf2/HO-1 pathway. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 72-76 33129943-11 2020 AST promoted the activation of Nrf2 and Ho-1 in the RGCs of the model mice. astaxanthine 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 31-35 32722441-0 2020 Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway in 661W Cell Model. astaxanthine 21-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 151-155 32722441-9 2020 Western blot analysis confirmed that astaxanthin activated the PI3K/Akt pathway, induced the nuclear translocation of Nrf2, and increased the expression of phase II antioxidant enzymes. astaxanthine 37-48 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 32405635-0 2020 Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 132-136 32340271-3 2020 It has been reported that ATX treatment induces antitumor effects via regulation of cell signaling pathways, including nuclear factor erythroid-derived 2-related factor 2 (Nrf2) signaling. astaxanthine 26-29 nuclear factor, erythroid derived 2, like 2 Mus musculus 119-170 32340271-3 2020 It has been reported that ATX treatment induces antitumor effects via regulation of cell signaling pathways, including nuclear factor erythroid-derived 2-related factor 2 (Nrf2) signaling. astaxanthine 26-29 nuclear factor, erythroid derived 2, like 2 Mus musculus 172-176 34677433-7 2021 Finally, we found that the expressions of heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) were significantly upregulated by astaxanthin in LPS-induced DCs, suggesting that the HO-1/Nrf2 pathway plays a significant role in the suppression of oxidative stress. astaxanthine 155-166 nuclear factor, erythroid derived 2, like 2 Mus musculus 70-113 34677433-7 2021 Finally, we found that the expressions of heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) were significantly upregulated by astaxanthin in LPS-induced DCs, suggesting that the HO-1/Nrf2 pathway plays a significant role in the suppression of oxidative stress. astaxanthine 155-166 nuclear factor, erythroid derived 2, like 2 Mus musculus 115-119 34677433-7 2021 Finally, we found that the expressions of heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) were significantly upregulated by astaxanthin in LPS-induced DCs, suggesting that the HO-1/Nrf2 pathway plays a significant role in the suppression of oxidative stress. astaxanthine 155-166 nuclear factor, erythroid derived 2, like 2 Mus musculus 212-216 34204220-6 2021 Furthermore, we found that astaxanthin inhibited the immune dysfunction of DCs induced by LPS via the activation of the HO-1/Nrf2 axis. astaxanthine 27-38 nuclear factor, erythroid derived 2, like 2 Mus musculus 125-129 33841672-0 2021 Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury via the Nrf2/HO-1 pathway. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 96-100 33841672-10 2021 RESULTS: The ATX treatment significantly improved the neurological status, promoted Nrf2 activation, and upregulated the expression of the Nrf2 and HO-1 mRNAs and the levels of the Nrf2, HO-1, and NQO1 proteins after TBI. astaxanthine 13-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 84-88 33841672-10 2021 RESULTS: The ATX treatment significantly improved the neurological status, promoted Nrf2 activation, and upregulated the expression of the Nrf2 and HO-1 mRNAs and the levels of the Nrf2, HO-1, and NQO1 proteins after TBI. astaxanthine 13-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 139-143 33841672-10 2021 RESULTS: The ATX treatment significantly improved the neurological status, promoted Nrf2 activation, and upregulated the expression of the Nrf2 and HO-1 mRNAs and the levels of the Nrf2, HO-1, and NQO1 proteins after TBI. astaxanthine 13-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 139-143 33326114-0 2021 Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/Nrf2/Prx2/ASK1/P38 after traumatic brain injury in mice. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 74-78 33326114-8 2021 Mechanically, ATX treatment dramatically enhanced the expression of peroxiredoxin 2 (Prx2), nuclear factor-erythroid 2-related factor 2 (Nrf2), and sirtuin 1 (SIRT1), while it downregulated the phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and p38. astaxanthine 14-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 92-135 33326114-8 2021 Mechanically, ATX treatment dramatically enhanced the expression of peroxiredoxin 2 (Prx2), nuclear factor-erythroid 2-related factor 2 (Nrf2), and sirtuin 1 (SIRT1), while it downregulated the phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and p38. astaxanthine 14-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 137-141 33326114-10 2021 Additionally, Nrf2 knockout abated the neuroprotective effects of ATX in TBI. astaxanthine 66-69 nuclear factor, erythroid derived 2, like 2 Mus musculus 14-18 33326114-13 2021 CONCLUSION AND IMPLICATIONS: ATX improved the neurologic functions and protected the brain from injury after TBI, primarily by reducing oxidative stress and neuronal death via SIRT1/Nrf2/Prx2/ASK1/p38 signaling pathway. astaxanthine 29-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 182-186 32279084-6 2020 Mechanistically, the effect of Astaxanthin was mediated by restoring the Nrf2/HO-1 antioxidant pathway in the liver of GDM mice. astaxanthine 31-42 nuclear factor, erythroid derived 2, like 2 Mus musculus 73-77 32673631-0 2020 Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice. astaxanthine 21-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 106-111 32673631-5 2020 ASX treatment also markedly inhibited the production of ROS and activated PI3K/AKT signaling, which facilitated the nuclear translocation of Nrf-2 and reversed the down-regulation of HO-1, NQO1 and GCLM proteins in the hippocampus that were induced by sub-chronic exposure to La2O3 NPs. astaxanthine 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 141-146 32197464-0 2020 Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway. astaxanthine 21-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 32190177-0 2020 Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 94-98 32190177-10 2020 ASX played a protective role by changing the expression of Keap1, Nrf2, HO-1, Bax, Bcl-2, Caspase3, and Caspase9 proteins. astaxanthine 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 66-70 32190177-11 2020 These results indicate that the protective mechanism of ASX on the myocardium works through the Keap1-Nrf2 signaling pathway and mitochondria-mediated apoptosis pathway. astaxanthine 56-59 nuclear factor, erythroid derived 2, like 2 Mus musculus 102-106 31795292-0 2019 Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 65-69 31795292-3 2019 Recent studies have shown that astaxanthin protects against oxidative stress via Nrf2. astaxanthine 31-42 nuclear factor, erythroid derived 2, like 2 Mus musculus 81-85 31795292-4 2019 In this study, we investigated the emphysema suppression effect of astaxanthin via Nrf2 in mice. astaxanthine 67-78 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-87 31795292-7 2019 Significantly increased expression levels of Nrf2 and its target gene, heme oxygenase-1 (HO-1), were found in the lung homogenates of astaxanthin-fed mice. astaxanthine 134-145 nuclear factor, erythroid derived 2, like 2 Mus musculus 45-49 31795292-9 2019 In conclusion, astaxanthin protects against oxidative stress via Nrf2 and ameliorates cigarette smoke-induced emphysema. astaxanthine 15-26 nuclear factor, erythroid derived 2, like 2 Mus musculus 65-69 31795292-10 2019 Therapy with astaxanthin directed toward activating the Nrf2 pathway has the potential to be a novel preventive and therapeutic strategy for COPD. astaxanthine 13-24 nuclear factor, erythroid derived 2, like 2 Mus musculus 56-60 31533259-0 2019 Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-kappaB Pathway. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 65-69 31772142-0 2019 Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 48-52 31772142-2 2019 Astaxanthin (Ast), a natural compound with remarkable antioxidant activity and multiple medical applications due to its activation of Nrf2 signaling, has been studied for application to various degenerative diseases. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 134-138 31772142-2 2019 Astaxanthin (Ast), a natural compound with remarkable antioxidant activity and multiple medical applications due to its activation of Nrf2 signaling, has been studied for application to various degenerative diseases. astaxanthine 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 134-138 31772142-5 2019 RESULTS: Ast attenuated ECM degradation of OA chondrocytes through the Nrf2 signaling, and ameliorated the IL-1beta-induced inflammatory response and ECM degradation via blockade of MAPK signaling. astaxanthine 9-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 71-75 31772142-8 2019 CONCLUSIONS: Ast could protect against osteoarthritis via the Nrf2 signaling, suggesting Ast might be a potential therapeutic supplement for OA treatment. astaxanthine 13-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 62-66 31772142-8 2019 CONCLUSIONS: Ast could protect against osteoarthritis via the Nrf2 signaling, suggesting Ast might be a potential therapeutic supplement for OA treatment. astaxanthine 89-92 nuclear factor, erythroid derived 2, like 2 Mus musculus 62-66 31772142-10 2019 Modulating effects of Ast on the Nrf2 signaling pathway, and damage-associated events including extracellular matrix (ECM) degradation, inflammation, oxidative stress, chondrocyte apoptosis, and in vivo cartilage degradation were examined. astaxanthine 22-25 nuclear factor, erythroid derived 2, like 2 Mus musculus 33-37 31598118-0 2019 Astaxanthin Ameliorates the Lipopolysaccharides-Induced Subfertility in Mouse via Nrf2/HO-1 Antioxidant Pathway. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 82-86 31598118-6 2019 Astaxanthin improves LPS-impaired spermatozoa motility, viability, morphology, and activity; reduces LPS-induced spermatozoa oxidative stress; and alleviates LPS-impaired fertilization and embryo development through activating Nrf2/HO-1 antioxidant signaling pathway. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 227-231 31533259-7 2019 In contrast with OTA, ASTA significantly raised the expression of Nrf2, HO-1, and MnSOD, while the expression of other proteins (Keap1, TLR4, and NF-kappaB) was significantly decreased. astaxanthine 22-26 nuclear factor, erythroid derived 2, like 2 Mus musculus 66-70 31533259-8 2019 These results indicate that ASTA exerted protective effects against OTA-induced oxidative damage and inflammation in the lung by regulating the Nrf2 and NF-kappaB pathways. astaxanthine 28-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 144-148 30268666-3 2018 The current study aimed to investigate whether astaxanthin (AST) could ameliorate the pathological progression of DN by upregulating Cx43 and activating the Nrf2/ARE signaling, which is a pivotal anti-oxidative stress system, to strengthen the cellular anti-oxidative capacity and diminish fibronectin (FN) accumulation in HG-induced glomerular mesangial cells (GMCs). astaxanthine 47-58 nuclear factor, erythroid derived 2, like 2 Mus musculus 157-161 31159211-7 2019 Meanwhile, mRNA of Nrf2 and Nrf2-dependent enzymes in mice heart were also downregulated in the ASX-treated groups. astaxanthine 96-99 nuclear factor, erythroid derived 2, like 2 Mus musculus 19-23 31159211-7 2019 Meanwhile, mRNA of Nrf2 and Nrf2-dependent enzymes in mice heart were also downregulated in the ASX-treated groups. astaxanthine 96-99 nuclear factor, erythroid derived 2, like 2 Mus musculus 28-32 31159211-9 2019 Our findings indicate that high-dose administration of astaxanthin can blunt antioxidant enzyme activity and downregulate transcription of Nrf2 and Nrf2-dependent enzymes along with attenuating plasma and muscle MDA. astaxanthine 55-66 nuclear factor, erythroid derived 2, like 2 Mus musculus 139-143 31159211-9 2019 Our findings indicate that high-dose administration of astaxanthin can blunt antioxidant enzyme activity and downregulate transcription of Nrf2 and Nrf2-dependent enzymes along with attenuating plasma and muscle MDA. astaxanthine 55-66 nuclear factor, erythroid derived 2, like 2 Mus musculus 148-152 30308382-5 2018 ASTX significantly decreased LPS-induced mRNA expression of interleukin 6 (Il-6) and Il-1beta by inhibiting nuclear translocation of NFkappaB p65; and attenuated LPS-induced ROS with an increase in NRF2 nuclear translocation, concomitantly decreasing NADPH oxidase 2 expression in RAW 264.7 macrophages. astaxanthine 0-4 nuclear factor, erythroid derived 2, like 2 Mus musculus 198-202 30308382-0 2018 Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 79-83 30308382-6 2018 In BMDM of WT and Nrf2-deficient mice, ASTX decreased basal and LPS-induced ROS accumulation. astaxanthine 39-43 nuclear factor, erythroid derived 2, like 2 Mus musculus 18-22 26197224-9 2015 Moreover, ATX also induced the HO-1 expression in a dose and time-dependent manner, increased the antioxidant-responsive element (ARE) activity and nuclear Nrf2 expression. astaxanthine 10-13 nuclear factor, erythroid derived 2, like 2 Mus musculus 156-160 29603113-3 2018 In this study, we aimed to investigate the epigenetic regulation of Nrf2 by astaxanthin (AST) and fucoxanthin (FX), carotenoids which are abundant in microalgae and seaweeds, in mouse skin epidermal JB6 P+ cells. astaxanthine 76-87 nuclear factor, erythroid derived 2, like 2 Mus musculus 68-72 29603113-3 2018 In this study, we aimed to investigate the epigenetic regulation of Nrf2 by astaxanthin (AST) and fucoxanthin (FX), carotenoids which are abundant in microalgae and seaweeds, in mouse skin epidermal JB6 P+ cells. astaxanthine 89-92 nuclear factor, erythroid derived 2, like 2 Mus musculus 68-72 28689962-0 2017 Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 57-61 28689962-2 2017 Astaxanthin also induces NF-E2-related factor 2 (Nrf2), which plays a major regulatory role in the antioxidative response. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 25-47 28689962-2 2017 Astaxanthin also induces NF-E2-related factor 2 (Nrf2), which plays a major regulatory role in the antioxidative response. astaxanthine 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 49-53 28689962-3 2017 However, little is known whether the carotenoid, by-products of astaxanthin, activate Nrf2. astaxanthine 64-75 nuclear factor, erythroid derived 2, like 2 Mus musculus 86-90 28689962-4 2017 Toward this end, we screened eight astaxanthin analogs for Nrf2 activation in murine photoreceptor cell line, 661 W, by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). astaxanthine 35-46 nuclear factor, erythroid derived 2, like 2 Mus musculus 59-63 28689962-8 2017 Nrf2-controlled genes Ho-1, Nqo-1, and Gclm by qRT-PCR and Nrf2 in the nucleus were upregulated in 661 W cells exposed astaxanthin, adonixanthin, echinenone, and lycopene. astaxanthine 119-130 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 28689962-8 2017 Nrf2-controlled genes Ho-1, Nqo-1, and Gclm by qRT-PCR and Nrf2 in the nucleus were upregulated in 661 W cells exposed astaxanthin, adonixanthin, echinenone, and lycopene. astaxanthine 119-130 nuclear factor, erythroid derived 2, like 2 Mus musculus 59-63 28689962-11 2017 These findings indicate that the more potent astaxanthin analogs, adonixanthin and lycopene, protect against light-induced cell damage through not only an anti-oxidative response but also through Nrf2 activation. astaxanthine 45-56 nuclear factor, erythroid derived 2, like 2 Mus musculus 196-200 26895661-8 2016 The antifibrogenic effect of ASTX was independent of nuclear erythroid 2-related factor 2 as it was observed in HSCs from wild-type and Nrf2(-/-) mice. astaxanthine 29-33 nuclear factor, erythroid derived 2, like 2 Mus musculus 136-140