PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33207669-3	2020	In the current review, the anti-inflammation mechanisms of astaxanthin involved in targeting for inflammatory biomarkers and multiple signaling pathways, including PI3K/AKT, Nrf2, NF-kappaB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3, have been described.	astaxanthine	59-70	mitogen-activated protein kinase 3	Homo sapiens	191-197	
20828541-10	2010	We also demonstrated that the specific ERK inhibitor, PD98059, concentration-dependently blocked on ATX-induced HO-1 expression, and meanwhile PD98059 reversed the protective effect of ATX against Abeta25-35-induced cell death.	astaxanthine	100-103	mitogen-activated protein kinase 3	Homo sapiens	39-42	
27693704-8	2016	Combination of pemetrexed and astaxanthin resulted in synergistic enhancing cytotoxicity and cell growth inhibition in NSCLC cells, accompanied with reduced activation of phospho-MKK1/2, phopho-ERK1/2, and TS expression.	astaxanthine	30-41	mitogen-activated protein kinase 3	Homo sapiens	194-200	
27693704-10	2016	Our findings suggested that the down-regulation of MKK1/2-ERK1/2-mediated TS expression by astaxanthin is an important regulator of enhancing the pemetrexed-induced cytotoxicity in NSCLC cells.	astaxanthine	91-102	mitogen-activated protein kinase 3	Homo sapiens	58-64	
20828541-0	2010	Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells.	astaxanthine	0-11	mitogen-activated protein kinase 3	Homo sapiens	60-66	
27693704-7	2016	Knockdown of TS using small interfering RNA (siRNA) or inhibiting ERK1/2 activity enhanced the cytotoxicity and cell growth inhibition of astaxanthin.	astaxanthine	138-149	mitogen-activated protein kinase 3	Homo sapiens	66-72	
24480614-6	2014	We found that astaxanthin reduced the expression of MMP-1, MMP-3 and MMP-13 as well as the phosphorylation of two mitogen-activated protein kinases (MAPK) (p38 and ERK1/2) in IL-1beta-stimulated chondrocytes.	astaxanthine	14-25	mitogen-activated protein kinase 3	Homo sapiens	149-153	
24480614-6	2014	We found that astaxanthin reduced the expression of MMP-1, MMP-3 and MMP-13 as well as the phosphorylation of two mitogen-activated protein kinases (MAPK) (p38 and ERK1/2) in IL-1beta-stimulated chondrocytes.	astaxanthine	14-25	mitogen-activated protein kinase 3	Homo sapiens	164-170	
20828541-10	2010	We also demonstrated that the specific ERK inhibitor, PD98059, concentration-dependently blocked on ATX-induced HO-1 expression, and meanwhile PD98059 reversed the protective effect of ATX against Abeta25-35-induced cell death.	astaxanthine	185-188	mitogen-activated protein kinase 3	Homo sapiens	39-42	
20828541-11	2010	Taken together, these findings suggest that astaxanthin can induce HO-1 expression through activation of ERK signal pathways, thereby protecting the SH-SY5Y cells from Abeta(25-35)-induced oxidative cell death.	astaxanthine	44-55	mitogen-activated protein kinase 3	Homo sapiens	105-108	
19014378-7	2008	In western blot analysis, 6-OHDA activated p38 MAPK, c-jun NH(2)-terminal kinase 1/2, and extracellular signal-regulated kinase 1/2, while Asx blocked the phosphorylation of p38 MAPK but not c-jun NH(2)-terminal kinase 1/2 and extracellular signal-regulated kinase 1/2.	astaxanthine	139-142	mitogen-activated protein kinase 3	Homo sapiens	191-268	
19014378-9	2008	Furthermore, Asx markedly abolished 6-OHDA-induced reactive oxygen species generation, which resulted in the blockade of p38 MAPK activation and apoptosis induced by 6-OHDA treatment.	astaxanthine	13-16	mitogen-activated protein kinase 3	Homo sapiens	125-129