PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26573554-7	2016	In human mast cells, sesamin reduced the stimulatory effects of phorbol 12-myristate 13-acetate and calcium ionophore A23187 on the production and secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6.	sesamin	21-28	interleukin 6	Homo sapiens	230-243	
22048871-9	2012	DNA-binding ELISA experiments revealed that (+)-episesamin treated HCC cells showed a suppressed basal and TNFalpha-induced activation of NF-kappaB and a subsequent suppression of TNFalpha- and LPS-induced IL-6 production.	sesamin	44-58	interleukin 6	Homo sapiens	206-210	
22048871-11	2012	Our findings show that anti-neoplastic effects of (+)-episesamin are mediated via suppressed activation of NF-kappaB which entails a decreased release of pro-inflammatory IL-6.	sesamin	50-64	interleukin 6	Homo sapiens	171-175	
30365050-8	2019	In addition, cotreatment with the COX2 inhibitor CAY10404 and sesamin downregulated the expression of downstream molecules of COX2 [including interleukin (IL)1beta, IL6 and tumor necrosis factor alpha] compared with CAY10404 or sesamin alone.	sesamin	62-69	interleukin 6	Homo sapiens	165-168	
29237438-13	2017	However, hSF cells were more sensitive to sesamin than SW982 cells in terms of the anti-RA effect.	sesamin	42-49	interleukin 6	Homo sapiens	9-12	
25845399-6	2015	In addition, the accumulation of TGF-alpha and interleukin-6 (IL-6) production induced by LPS in the culture supernatant was found to be decreased dose-dependently with sesamin pretreatment in PC3 cells using the enzyme-linked immunosorbent assay (ELISA) kit.	sesamin	169-176	interleukin 6	Homo sapiens	47-60	
25845399-6	2015	In addition, the accumulation of TGF-alpha and interleukin-6 (IL-6) production induced by LPS in the culture supernatant was found to be decreased dose-dependently with sesamin pretreatment in PC3 cells using the enzyme-linked immunosorbent assay (ELISA) kit.	sesamin	169-176	interleukin 6	Homo sapiens	62-66	
25038821-12	2014	Treatment with sesamin significantly reduced the expression of nuclear NF-kappaB, IL-6, p-Stat3, Twist and Vimentin (a mesenchymal marker) in SP cells.	sesamin	15-22	interleukin 6	Homo sapiens	82-86	
25038821-13	2014	Nuclear NF-kappaB activity and IL-6 level were also decreased after treatment with sesamin.	sesamin	83-90	interleukin 6	Homo sapiens	31-35	
25038821-14	2014	CONCLUSION: Food-derived sesamin directs the epithelial differentiation of cancer stem-like SP cells from GBC, which is associated with attenuation of NF-kappaB-IL-6-Stat3-Twist signal pathway.	sesamin	25-32	interleukin 6	Homo sapiens	161-165	
24088253-4	2013	Furthermore, sesamin suppressed the constitutive and interleukin (IL)-6-induced signal transducer and activator of transcription 3 (STAT3) signalling pathway in HepG2 cells, leading to regulate the downstream genes, including p53, p21, cyclin proteins and the Bcl-2 protein family.	sesamin	13-20	interleukin 6	Homo sapiens	53-71