PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31976003-6	2019	Sesamin was applied to the hepatic HepaRG and intestinal LS174T cells and showed that it markedly ameliorated lipid accumulation in the HepaRG cells, by reducing LXRalpha transactivation, inhibiting the expression of downstream target genes.	sesamin	0-7	nuclear receptor subfamily 1 group H member 3	Homo sapiens	162-170	
31976003-0	2019	Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRalpha) and Pregnane X Receptor (PXR).	sesamin	0-7	nuclear receptor subfamily 1 group H member 3	Homo sapiens	124-132	
31976003-5	2019	Reporter assays, mRNA and protein expression, and in silico modeling were used to identify sesamin as an antagonist of LXRalpha.	sesamin	91-98	nuclear receptor subfamily 1 group H member 3	Homo sapiens	119-127	
31976003-10	2019	Additionally, sesamin reduced valproate- and rifampin-induced LXRalpha and pregnane X receptor (PXR) transactivation.	sesamin	14-21	nuclear receptor subfamily 1 group H member 3	Homo sapiens	62-70	
31976003-12	2019	Thus, sesamin is an antagonist of LXRalpha and PXR and suggests that it may alleviate drug-induced lipogenesis via the suppression of LXRalpha and PXR signaling.	sesamin	6-13	nuclear receptor subfamily 1 group H member 3	Homo sapiens	34-42	
31976003-12	2019	Thus, sesamin is an antagonist of LXRalpha and PXR and suggests that it may alleviate drug-induced lipogenesis via the suppression of LXRalpha and PXR signaling.	sesamin	6-13	nuclear receptor subfamily 1 group H member 3	Homo sapiens	134-142