PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21900690-6 2011 The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). pyrazolanthrone 18-26 insulin receptor substrate 1 Homo sapiens 50-55 21900690-6 2011 The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). pyrazolanthrone 18-26 insulin receptor substrate 1 Homo sapiens 89-94 21900690-6 2011 The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). pyrazolanthrone 18-26 insulin receptor substrate 1 Homo sapiens 89-94 21478152-7 2011 Inhibition of JNK (with JNK inhibitor SP600125 or using dominant-negative JNK) reduced serine 307 phosphorylation of IRS1. pyrazolanthrone 38-46 insulin receptor substrate 1 Homo sapiens 117-121 16099428-1 2005 In 3T3-L1 adipocytes, insulin or anisomycin stimulated phosphorylation of IRS-1 at Ser(307) and Ser(636/639), both of which were partially reduced by the mTOR inhibitor, rapamycin, or the JNK inhibitor, SP600125, and were further inhibited by a combination of them. pyrazolanthrone 203-211 insulin receptor substrate 1 Homo sapiens 74-79 12409308-9 2003 SP600125, a JNK inhibitor, prevented PMA and TNFalpha-induced IRS1 Ser-307 phosphorylation. pyrazolanthrone 0-8 insulin receptor substrate 1 Homo sapiens 62-66