PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31856338-0 2020 Inhibition of noncanonical Wnt pathway overcomes enzalutamide resistance in castration-resistant prostate cancer. enzalutamide 49-61 Wnt family member 5A Homo sapiens 27-30 31856338-11 2020 This was validated by the elevated expression of noncanonical Wnt pathway members such as Wnt5a, RhoA, and ROCK in enzalutamide-resistant PCa cells in comparison to their enzalutamide-sensitive counterparts. enzalutamide 171-183 Wnt family member 5A Homo sapiens 62-65 31856338-11 2020 This was validated by the elevated expression of noncanonical Wnt pathway members such as Wnt5a, RhoA, and ROCK in enzalutamide-resistant PCa cells in comparison to their enzalutamide-sensitive counterparts. enzalutamide 171-183 Wnt family member 5A Homo sapiens 90-95 31856338-15 2020 CONCLUSIONS: The noncanonical Wnt pathway is activated in enzalutamide-resistant PCa and inhibition of noncanonical Wnt pathway overcomes enzalutamide resistance and enhances its efficacy in CRPC. enzalutamide 58-70 Wnt family member 5A Homo sapiens 30-33 31856338-15 2020 CONCLUSIONS: The noncanonical Wnt pathway is activated in enzalutamide-resistant PCa and inhibition of noncanonical Wnt pathway overcomes enzalutamide resistance and enhances its efficacy in CRPC. enzalutamide 138-150 Wnt family member 5A Homo sapiens 30-33 31856338-15 2020 CONCLUSIONS: The noncanonical Wnt pathway is activated in enzalutamide-resistant PCa and inhibition of noncanonical Wnt pathway overcomes enzalutamide resistance and enhances its efficacy in CRPC. enzalutamide 138-150 Wnt family member 5A Homo sapiens 116-119 31856338-10 2020 RESULTS: We found that the noncanonical Wnt signaling was activated in enzalutamide-resistant PCa cells and that the activation of noncanonical Wnt signaling was correlated with AR expression and disease progression. enzalutamide 71-83 Wnt family member 5A Homo sapiens 40-43 31856338-11 2020 This was validated by the elevated expression of noncanonical Wnt pathway members such as Wnt5a, RhoA, and ROCK in enzalutamide-resistant PCa cells in comparison to their enzalutamide-sensitive counterparts. enzalutamide 115-127 Wnt family member 5A Homo sapiens 62-65 31856338-11 2020 This was validated by the elevated expression of noncanonical Wnt pathway members such as Wnt5a, RhoA, and ROCK in enzalutamide-resistant PCa cells in comparison to their enzalutamide-sensitive counterparts. enzalutamide 115-127 Wnt family member 5A Homo sapiens 90-95