PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32699265-10	2021	Artesunate-induced lysosome activation synergized with sorafenib-mediated pro-oxidative effects by promoting sequential reactions including lysosomal cathepsin B/L activation, ferritin degradation, lipid peroxidation, and consequent ferroptosis.	Sorafenib	55-64	cathepsin B	Homo sapiens	150-161	
26097873-0	2015	Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway.	Sorafenib	0-9	cathepsin B	Homo sapiens	18-29	
26097873-7	2015	The sorafenib-increased cathepsin B activity induced the proteolysis of Bid into tBid that stimulates the intrinsic pathway of apoptosis characterized by mitochondrial membrane depolarization, oxygen radical generation and cytochrome c release.	Sorafenib	4-13	cathepsin B	Homo sapiens	24-35	
26097873-8	2015	Moreover, we found that cathepsin B enzymatic activity, induced by sorafenib, is dependent on its dephosphorylation via PTEN activation and Akt inactivation.	Sorafenib	67-76	cathepsin B	Homo sapiens	24-35	
26097873-11	2015	Overall, our results show that apoptotic cell death induced by sorafenib in bladder cancer cells is dependent on cathepsin B activity and involved PTEN and Akt signaling pathways.	Sorafenib	63-72	cathepsin B	Homo sapiens	113-124