PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25614335-0	2015	Cyclophilin D-mediated apoptosis attributes to sorafenib-induced cytotoxicity in clear cell-renal cell carcinoma.	Sorafenib	47-56	peptidylprolyl isomerase F	Homo sapiens	0-13	
25614335-2	2015	The aim of this study was to assess the effects of the multi-target drug, sorafenib, on clear cell-renal cell carcinoma (ccRCC) necrosis by regulating CypD expression and to explore whether this effect was related to the phosphorylation of extracellular signal-regulated kinases (ERKs).	Sorafenib	74-83	peptidylprolyl isomerase F	Homo sapiens	151-155	
25614335-7	2015	Sorafenib induced the apoptosis of 786-O cells, which was coupled with the upregulation of CypD.	Sorafenib	0-9	peptidylprolyl isomerase F	Homo sapiens	91-95	
25614335-8	2015	Cyclosporin A (CsA, the inhibitor of CypD) and CypD siRNA inhibited the effect of sorafenib on apoptosis-induced 786-O and mitochondrial membrane potential depolarization.	Sorafenib	82-91	peptidylprolyl isomerase F	Homo sapiens	47-51	
25614335-9	2015	Epidermal growth factor (EGF, the activator of ERK) and ERK overexpression inhibited the effect of sorafenib on CypD expression, apoptosis-induced 786-O and mitochondrial membrane potential depolarization.	Sorafenib	99-108	peptidylprolyl isomerase F	Homo sapiens	112-116	
25614335-11	2015	Sorafenib induced apoptosis in ccRCC through CypD upregulation and this effect was related to the inhibition of p-ERK.	Sorafenib	0-9	peptidylprolyl isomerase F	Homo sapiens	45-49