PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33573585-10	2021	RESULTS: Dantrolene exhibited synergistic effect when used in combination with sorafenib compared to either drug alone (p <0.05) through decreasing p53, VEGF, MMP-9, Cyclin D1, and Ki-67.	Sorafenib	79-88	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	148-151	
33791811-9	2021	Also, sorafenib significantly decreased the levels of P21, CyclinD1, CDK4 and proliferating cell nuclear antigen, as well as up-regulated P53 expression in adjuvant arthritis fibroblast-like synoviocytes.	Sorafenib	6-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	138-141	
33791811-10	2021	CONCLUSIONS: Sorafenib could inhibit adjuvant arthritis fibroblast-like synoviocytes proliferation via arresting G1/S cell cycle progression, which was partially through CDK4/CyclinD1-mediated pathway, as well as up-regulating P53 and down-regulating proliferating cell nuclear antigen expressions.	Sorafenib	13-22	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	227-230