PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33203790-0 2020 Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma. Sorafenib 48-57 kinesin family member 14 Mus musculus 10-15 33203790-4 2020 We identified KIF14 as an oncogene involved in the acquired resistance to sorafenib in HCC and investigated its potential as a target for reversing this resistance. Sorafenib 74-83 kinesin family member 14 Mus musculus 14-19 33203790-5 2020 Sustained exposure of resistant HCC cells to sorafenib activated the AKT pathway, which in turn upregulated KIF14 expression by increasing expression of the transcription factor ETS1. Sorafenib 45-54 kinesin family member 14 Mus musculus 108-113 33203790-6 2020 Silencing KIF14 reversed the acquired resistance to sorafenib by inhibiting AKT activation and downregulating ETS1 expression by blocking the AKT-ETS1-KIF14 positive feedback loop. Sorafenib 52-61 kinesin family member 14 Mus musculus 10-15 33203790-6 2020 Silencing KIF14 reversed the acquired resistance to sorafenib by inhibiting AKT activation and downregulating ETS1 expression by blocking the AKT-ETS1-KIF14 positive feedback loop. Sorafenib 52-61 kinesin family member 14 Mus musculus 151-156 33203790-8 2020 These results demonstrate that targeting KIF14 could be an effective means of reversing sorafenib failure or strengthening sorafenib"s antitumor effects. Sorafenib 88-97 kinesin family member 14 Mus musculus 41-46