PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32599324-3	2020	In the course of our investigations to discover new CDK8 inhibitors, we designed and synthesized tricyclic pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives, by introduction of chemical complexity in the multi-kinase inhibitor Sorafenib taking into account the flexibility of the P-loop motif of CDK8 protein observed after analysis of structural information of co-crystallized CDK8 inhibitors.	Sorafenib	230-239	cyclin dependent kinase 8	Homo sapiens	52-56	
27326333-1	2016	Using Sorafenib as a starting point, a series of potent and selective inhibitors of CDK8 was developed.	Sorafenib	6-15	cyclin dependent kinase 8	Homo sapiens	84-88	
21806996-3	2011	We have solved the 2.2-A crystal structure of CDK8/CycC in complex with sorafenib, an anti-cancer drug of clinical relevance.	Sorafenib	72-81	cyclin dependent kinase 8	Homo sapiens	46-50	
21806996-7	2011	Sorafenib binds to the catalytic cleft of CDK8.	Sorafenib	0-9	cyclin dependent kinase 8	Homo sapiens	42-46