PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23231952-8 2013 Sorafenib also blocks Mcl-1 and cyclin D1 translation, which promotes an imbalance between pro- and antiapoptotic proteins and facilitates Bax release from cyclin D1, leading to the induction of mitochondrial apoptosis and caspase-dependent and -independent mechanisms. Sorafenib 0-9 cyclin D1 Mus musculus 32-41 23231952-8 2013 Sorafenib also blocks Mcl-1 and cyclin D1 translation, which promotes an imbalance between pro- and antiapoptotic proteins and facilitates Bax release from cyclin D1, leading to the induction of mitochondrial apoptosis and caspase-dependent and -independent mechanisms. Sorafenib 0-9 cyclin D1 Mus musculus 156-165 21319287-11 2012 Sorafenib inhibited cyclinD1 expression and cell proliferation in tumors, and volumetric measurements identified significant decreases in tumor volume in some mice. Sorafenib 0-9 cyclin D1 Mus musculus 20-28 22406995-9 2012 Sorafenib inhibited expression of cyclin E, cyclin D1/D2/D3, key regulators for cell cycle, and the antiapoptotic proteins Mcl-1 and survivin. Sorafenib 0-9 cyclin D1 Mus musculus 44-53 20884624-8 2010 Our data showed that sorafenib downregulated phospho-STAT3 (pSTAT3) and subsequently reduced the expression levels of STAT3-related proteins (Mcl-1, survivin, and cyclin D1) in a dose- and time-dependent manner in TRAIL-treated HCC cells. Sorafenib 21-30 cyclin D1 Mus musculus 163-172