PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33842334-7 2021 Application of AhR inhibitor DMF could efficiently suppress distant metastasis of renal cancer cells, and improve anticancer effects of sorafenib (Sor)/sunitinib (Sun), which described a promising therapeutic strategy for clinical renal cancer. Sorafenib 136-145 aryl hydrocarbon receptor Homo sapiens 15-18 33842334-7 2021 Application of AhR inhibitor DMF could efficiently suppress distant metastasis of renal cancer cells, and improve anticancer effects of sorafenib (Sor)/sunitinib (Sun), which described a promising therapeutic strategy for clinical renal cancer. Sorafenib 147-150 aryl hydrocarbon receptor Homo sapiens 15-18 35124147-0 2022 Sorafenib is an antagonist of the aryl hydrocarbon receptor. Sorafenib 0-9 aryl hydrocarbon receptor Homo sapiens 34-59 35124147-11 2022 Sorafenib"s antagonistic action on AhR was comparable to that of the known AhR antagonist CH-223191 in human liver and ovarian cell lines. Sorafenib 0-9 aryl hydrocarbon receptor Homo sapiens 35-38 35124147-12 2022 In summary, we demonstrate that sorafenib is a potent AhR antagonist and likely endocrine disruptor of the AhR. Sorafenib 32-41 aryl hydrocarbon receptor Homo sapiens 54-57 35124147-12 2022 In summary, we demonstrate that sorafenib is a potent AhR antagonist and likely endocrine disruptor of the AhR. Sorafenib 32-41 aryl hydrocarbon receptor Homo sapiens 107-110 35124147-13 2022 Moreover, sorafenib offers potential benefit for diseases treatable through AhR suppression strategies. Sorafenib 10-19 aryl hydrocarbon receptor Homo sapiens 76-79 35124147-14 2022 Further investigation is warranted into sorafenib"s AhR antagonistic behavior. Sorafenib 40-49 aryl hydrocarbon receptor Homo sapiens 52-55