PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21844014-10 2011 RESULTS: The combination of riluzole with sorafenib exhibited enhanced antitumor activities in GRM1-expressing melanoma cells harboring either wild-type or mutated B-RAF. Sorafenib 42-51 glutamate metabotropic receptor 1 Homo sapiens 95-99 21844014-11 2011 The combination of riluzole with PLX4720 showed lessened efficacy compared with the combination of riluzole and sorafenib in suppressing the growth of GRM1-expressing cells harboring the B-RAF(V600E) mutation. Sorafenib 112-121 glutamate metabotropic receptor 1 Homo sapiens 151-155 21844014-12 2011 CONCLUSIONS: The combination of riluzole with sorafenib seems potent in suppressing tumor proliferation in vitro and in vivo in GRM1-expressing melanoma cells regardless of B-RAF genotype and may be a viable therapeutic clinical combination. Sorafenib 46-55 glutamate metabotropic receptor 1 Homo sapiens 128-132