PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34786210-0 2021 Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma. Sorafenib 38-47 heterogeneous nuclear ribonucleoprotein A2/B1 Homo sapiens 74-83 34786210-9 2021 Downregulating the expression of hnRNPA2B1 with siRNA could decrease the expression of PKM2 and enhance sorafenib-induced apoptosis in HepG2 cells. Sorafenib 104-113 heterogeneous nuclear ribonucleoprotein A2/B1 Homo sapiens 33-42 34786210-10 2021 Our study demonstrated that ER stress could promote sorafenib resistance through upregulating PKM2 via miR-188-5p/hnRNPA2B1. Sorafenib 52-61 heterogeneous nuclear ribonucleoprotein A2/B1 Homo sapiens 114-123 34786210-11 2021 Therefore, targeting the miR-188-5p/hnRNPA2B1/PKM2 pathway and ER stress may prove instrumental in overcoming sorafenib resistance in HCC treatment. Sorafenib 110-119 heterogeneous nuclear ribonucleoprotein A2/B1 Homo sapiens 36-45