PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29061583-6 2018 In addition, recombinant NRF2-siRNA was effective to sensitize both 143B and MG63 cells to doxorubicin, cisplatin, and sorafenib, which was associated with significant downregulation of NRF2-targeted ATP-binding cassette (ABC) efflux transporters (ABCC3, ABCC4, and ABCG2). Sorafenib 119-128 ATP binding cassette subfamily C member 3 Homo sapiens 248-253 26769852-0 2016 MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma. Sorafenib 38-47 ATP binding cassette subfamily C member 3 Homo sapiens 0-4 26769852-8 2016 When MRP3 gene was knocked down by siRNA in PLC-PRF5-R2 cells, the sensitivity of the cells to sorafenib was restored. Sorafenib 95-104 ATP binding cassette subfamily C member 3 Homo sapiens 5-9 26769852-10 2016 Our data clearly demonstrate that the efflux transporter MRP3 plays an important role in resistance to sorafenib in HCC cells. Sorafenib 103-112 ATP binding cassette subfamily C member 3 Homo sapiens 57-61 33220273-7 2021 EX-527 reduced MRP3 and BCRP expression in sorafenib-treated HCC cells. Sorafenib 43-52 ATP binding cassette subfamily C member 3 Homo sapiens 15-19 33220273-8 2021 Since ABC transporters contribute to MDR, MRP3 and BCRP could be also influencing in the response of HCC cells to sorafenib. Sorafenib 114-123 ATP binding cassette subfamily C member 3 Homo sapiens 42-46