PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31087496-7	2019	Moreover, a further miRNAs screen by qRT-PCR indicated that miR-124-3p and miR-506-3p (miR-124/506) were remarkably reduced in sorafenib insensitive patients.	Sorafenib	127-136	microRNA 506	Homo sapiens	87-98	
31087496-9	2019	Interestingly, we finally proved that the sorafenib resistant cells regained sensitivity for sorafenib by EZH2 intervention with miR-124/506 overexpression or EZH2 inhibitor treatment in vitro and in vivo, which will lead to the decreased tri-methylation at lysine 27 of histone H3 (H3K27me3) and increased acetylated lysine 27 of histone H3 (H3K27ac) levels.	Sorafenib	42-51	microRNA 506	Homo sapiens	129-140	
31087496-9	2019	Interestingly, we finally proved that the sorafenib resistant cells regained sensitivity for sorafenib by EZH2 intervention with miR-124/506 overexpression or EZH2 inhibitor treatment in vitro and in vivo, which will lead to the decreased tri-methylation at lysine 27 of histone H3 (H3K27me3) and increased acetylated lysine 27 of histone H3 (H3K27ac) levels.	Sorafenib	93-102	microRNA 506	Homo sapiens	129-140	
33000204-0	2020	KCNQ1OT1 contributes to sorafenib resistance and programmed death-ligand-1-mediated immune escape via sponging miR-506 in hepatocellular carcinoma cells.	Sorafenib	24-33	microRNA 506	Homo sapiens	111-118	
33000204-8	2020	KCNQ1OT1 and PD-L1 were found to be upregulated and miR-506 was downregulated in sorafenib-resistant HCC tissues and cells.	Sorafenib	81-90	microRNA 506	Homo sapiens	52-59	
33000204-11	2020	In addition, it was demonstrated that KCNQ1OT1 functioned as a competing endogenous RNA of miR-506 and increased PD-L1 expression in sorafenib-resistant HCC cells.	Sorafenib	133-142	microRNA 506	Homo sapiens	91-98	
33000204-12	2020	miR-506 inhibition abolished the effects of KCNQ1OT1 knockdown on sorafenib sensitivity, tumor growth, the tumor microenvironment and T-cell apoptosis.	Sorafenib	66-75	microRNA 506	Homo sapiens	0-7	
33000204-13	2020	In conclusion, KCNQ1OT1 knockdown inhibited sorafenib resistance and PD-L1-mediated immune escape by sponging miR-506 in sorafenib-resistant HCC cells.	Sorafenib	121-130	microRNA 506	Homo sapiens	110-117