PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33000204-0 2020 KCNQ1OT1 contributes to sorafenib resistance and programmed death-ligand-1-mediated immune escape via sponging miR-506 in hepatocellular carcinoma cells. Sorafenib 24-33 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 0-8 33000204-3 2020 The aim of the present study was to investigate the role of KCNQ1OT1 in sorafenib resistance and immune escape of HCC cells. Sorafenib 72-81 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 60-68 33000204-8 2020 KCNQ1OT1 and PD-L1 were found to be upregulated and miR-506 was downregulated in sorafenib-resistant HCC tissues and cells. Sorafenib 81-90 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 0-8 33000204-9 2020 Furthermore, KCNQ1OT1 knockdown reduced the IC50 value of sorafenib, suppressed cell metastasis and promoted apoptosis in sorafenib-resistant HCC cells. Sorafenib 58-67 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 13-21 33000204-9 2020 Furthermore, KCNQ1OT1 knockdown reduced the IC50 value of sorafenib, suppressed cell metastasis and promoted apoptosis in sorafenib-resistant HCC cells. Sorafenib 122-131 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 13-21 33000204-10 2020 Moreover, KCNQ1OT1 knockdown changed the tumor microenvironment and T-cell apoptosis in a sorafenib-resistant HCC/T-cell co-culture model. Sorafenib 90-99 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 10-18 33000204-11 2020 In addition, it was demonstrated that KCNQ1OT1 functioned as a competing endogenous RNA of miR-506 and increased PD-L1 expression in sorafenib-resistant HCC cells. Sorafenib 133-142 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 38-46 33000204-12 2020 miR-506 inhibition abolished the effects of KCNQ1OT1 knockdown on sorafenib sensitivity, tumor growth, the tumor microenvironment and T-cell apoptosis. Sorafenib 66-75 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 44-52 33000204-13 2020 In conclusion, KCNQ1OT1 knockdown inhibited sorafenib resistance and PD-L1-mediated immune escape by sponging miR-506 in sorafenib-resistant HCC cells. Sorafenib 44-53 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 15-23 33000204-13 2020 In conclusion, KCNQ1OT1 knockdown inhibited sorafenib resistance and PD-L1-mediated immune escape by sponging miR-506 in sorafenib-resistant HCC cells. Sorafenib 121-130 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 15-23