PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31002342-9 2019 Mechanistically, MLN4924 enhanced the antitumor activity of sorafenib in HCC cells via upregulation of cullin-RING E3 ubiquitin ligase (CRL)/Skp1-Cullin1-F box (SCF) E3 ubiquitin ligase substrates p21, p27, Deptor and IkappaBalpha. Sorafenib 60-69 DEP domain containing MTOR interacting protein Homo sapiens 207-213