PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34977009-9 2021 Finally, an overall survival assay further revealed that both a high expression of YAP and a low expression of GPX4 were correlated with increased survival of HCC patients with sorafenib treatment, which had been proven to be an inducer for ferroptosis by inhibition of the xc-amino acid antiporter. Sorafenib 177-186 glutathione peroxidase 4 Homo sapiens 111-115 34530350-6 2021 The overexpression of GPX4 or activation of Keap1/Nrf2 reverses the effects of the downregulation of SIRT6 on sorafenib-induced ferroptosis. Sorafenib 110-119 glutathione peroxidase 4 Homo sapiens 22-26 34530350-7 2021 Thus, targeting the SIRT6/Keap1/Nrf2/GPX4 signalling pathway may be a potential strategy for overcoming sorafenib resistance in GC. Sorafenib 104-113 glutathione peroxidase 4 Homo sapiens 37-41