PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32199349-9	2020	In summary, these results demonstrate that sorafenib promotes AA FLS apoptosis, which may be related to the upregulation of Fas and Caspase-3 and downregulation of NF-kappaB and C-jun.	Sorafenib	43-52	caspase 3	Rattus norvegicus	132-141	
32199349-8	2020	There were significant increases in the expression levels of Fas, Caspase-3 and Mcl-1, and significant decreases in NF-kappaB and C-jun expression in AA FLSs treated with sorafenib.	Sorafenib	171-180	caspase 3	Rattus norvegicus	66-75	
32509153-8	2020	Moreover, sorafenib caused upregulation of both gene and protein for the apoptotic markers cleaved Caspase-3, Bax, and Bid, and downregulation of the antiapoptotic protein Bcl-2.	Sorafenib	10-19	caspase 3	Rattus norvegicus	99-108	
20921950-16	2011	Although no change in PARP cleavage and only a minor increase in hepatic caspase-3 activity were detected in BDL rats in response to sorafenib, livers of sorafenib-treated BDL rats contained small DNA fragments, which were not observed in untreated BDL rats.	Sorafenib	133-142	caspase 3	Rattus norvegicus	73-82	
20447716-6	2010	Moreover, sorafenib downregulated Cyclin D1 and Cyclin-dependent kinase 4 (Cdk-4), simultaneously increased expression of Fas, Fas-L, and Caspase-3, and decreased the ratio of Bcl-2 to Bax.	Sorafenib	10-19	caspase 3	Rattus norvegicus	138-147