PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26189429-5	2016	We find that vemurafenib anti-BRAF(V600E) therapy significantly reduces secreted VEGFA, VEGFC and IL6 protein levels compared to vehicle-treated ATC cells.	Vemurafenib	13-24	interleukin 6	Homo sapiens	98-101	
32173467-0	2020	Transcripts 202 and 205 of IL-6 confer resistance to Vemurafenib by reactivating the MAPK pathway in BRAF(V600E) mutant melanoma cells.	Vemurafenib	53-64	interleukin 6	Homo sapiens	27-31	
32173467-11	2020	Neutralizing IL-6 significantly increased the sensitivity of drug-resistant cells to Vemurafenib.	Vemurafenib	85-96	interleukin 6	Homo sapiens	13-17	
32382617-7	2020	For more insight please see Transcripts 202 and 205 of IL-6 confer resistance to Vemurafenib by reactivating the MAPK pathway in BRAF(V600E) mutant melanoma cells [1].	Vemurafenib	81-92	interleukin 6	Homo sapiens	55-59	
30320916-8	2019	Further studies showed that interleukin 6 (IL-6) secretion increased after RKO cells were treated with vemurafenib.	Vemurafenib	103-114	interleukin 6	Homo sapiens	28-41	
30320916-8	2019	Further studies showed that interleukin 6 (IL-6) secretion increased after RKO cells were treated with vemurafenib.	Vemurafenib	103-114	interleukin 6	Homo sapiens	43-47	
30320916-9	2019	STAT3 activation was induced by adding IL-6 to the supernatant, and IL-6 increased STAT3 and BCL-2 expression and antagonized vemurafenib sensitivity in HT-29 cells.	Vemurafenib	126-137	interleukin 6	Homo sapiens	68-72	
29969659-4	2018	Mechanistically, exposure to PLX4032 enhanced IL6 secretion and this, in turn, was responsible for STAT3 upregulation, activation of ERK signaling and poor sensitivity to BRAF inhibition.	Vemurafenib	29-36	interleukin 6	Homo sapiens	46-49	
29969659-5	2018	Consistently, the dual blockade of STAT3 (by siRNA or pharmacological inhibition) or IL6 signaling (by the humanized anti-human IL6 receptor antibody, tocilizumab) and BRAF (by PLX4032) improved the inhibition of cell cycle progression compared to PLX4032 single agent.	Vemurafenib	177-184	interleukin 6	Homo sapiens	85-88