PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25633180-7	2015	17-AAG pretreatment induced the degradation of upstream regulators of IkappaB, IL-1R-associated kinase-1 (IRAK-1), and IkappaB kinases (IKKs), dose and time dependently, which resulted in blocking of PS-341-induced IkappaBalpha degradation, p65 nuclear translocation, transcriptional activity, and NF-kappaB-regulated antiapoptotic gene expressions such as COX-2.	tanespimycin	0-6	NFKB inhibitor alpha	Homo sapiens	215-227	
18974397-4	2008	Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) blocks MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is mediated by IkappaB kinase, which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation.	tanespimycin	41-79	NFKB inhibitor alpha	Homo sapiens	253-265