PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32129352-6 2020 We also found that rosmarinic acid inhibited ethanol-induced mRNA expression of tumor necrosis factor-alpha and interleukin 6. rosmarinic acid 19-34 interleukin 6 Mus musculus 112-125 34658856-13 2021 Our results predicted that astragalin and rosmarinic acid might regulate the JAK-STAT pathway by targeting PIM2 and STAT1, respectively, while paeoniflorin and rosmarinic acid were likely to regulate inflammatory responses by targeting TNFalpha, IL-6, and IL-4 during T2D. rosmarinic acid 42-57 interleukin 6 Mus musculus 246-250 34658856-13 2021 Our results predicted that astragalin and rosmarinic acid might regulate the JAK-STAT pathway by targeting PIM2 and STAT1, respectively, while paeoniflorin and rosmarinic acid were likely to regulate inflammatory responses by targeting TNFalpha, IL-6, and IL-4 during T2D. rosmarinic acid 160-175 interleukin 6 Mus musculus 246-250 34250696-13 2021 Rosmarinic acid downregulated the cytokines like interleukin-6, tumor necrosis factor-alpha, interleukin-1beta; inflammatory parameter includes prostaglandin E2 , cyclooxygenase-2, and inducible nitric oxide synthase at a dose-dependently. rosmarinic acid 0-15 interleukin 6 Mus musculus 49-62 33712964-6 2021 In addition, transethosomes-in-gel containing RA (RA-TE-Gel) formulations produced a great reduction in the punch edema (P < 0.001) and in TNF-alpha and IL-6 (P < 0.05). rosmarinic acid 46-48 interleukin 6 Mus musculus 153-157 19295475-2 2009 Results showed that RA concentration dependently down-regulated the levels of TNF-alpha, IL-6, and high-mobility group box 1 protein in LPS-induced RAW264.7 cells, inhibited the IkappaB kinase pathway, and modulated nuclear factor-kappaB. rosmarinic acid 20-22 interleukin 6 Mus musculus 89-93 26804033-6 2016 RA failed to mitigate the inflammatory response in most models, while it clearly reduced IL-6 and CXCL1/KC gene expression in murine PCIS at non-toxic concentrations. rosmarinic acid 0-2 interleukin 6 Mus musculus 89-93 31680772-5 2019 The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4+/CD8+ and the secretion of interleukin (IL)-2 and interferon-gamma, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2. rosmarinic acid 24-26 interleukin 6 Mus musculus 202-206 29691532-4 2018 Our results showed that BRAE decreased the histological score and TNF-alpha mRNA expression in a dose-dependent manner, while BRAE + RA dose-dependently attenuated the histological score and mRNA expression of IL-6. rosmarinic acid 25-27 interleukin 6 Mus musculus 210-214 29204872-5 2018 ELISA and qPCR results indicated that RA dose-dependently decreased the expression of TNF-alpha, IL-1beta, and IL-6 both in tissues and mMECs. rosmarinic acid 38-40 interleukin 6 Mus musculus 111-115 28840833-10 2017 RA treatments lowered the hepatic level of IL-6, TNF-alpha, and PGE2, as well as the activity of COX-2 (p < 0.05). rosmarinic acid 0-2 interleukin 6 Mus musculus 43-47 28383063-7 2017 In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis. rosmarinic acid 13-15 interleukin 6 Mus musculus 89-93 29131114-6 2017 RESULTS: RA attenuated the expression of the M1 marker iNOS and the levels of proinflammatory factors, including TNF-alpha, IL-1beta, and IL-6; it increased the expression of the M2 marker Arg-1, and inhibited, at least in part, ROS generation and loss of mitochondrial outer membrane permeabilization through the inhibition of cleaved caspase-3 activation. rosmarinic acid 9-11 interleukin 6 Mus musculus 138-142 22441336-5 2012 RA significantly decreased the production of LPS-induced TNF-a, IL-6, and IL-1beta compare with the LPS group. rosmarinic acid 0-2 interleukin 6 Mus musculus 64-68 21239739-13 2011 Protein levels and mRNA expressions of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha were inhibited by EPPF or RA administration in the nasal mucosa tissue or spleen of OVA-sensitized mice. rosmarinic acid 126-128 interleukin 6 Mus musculus 63-99