PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22167582-9	2012	Increased apoptosis monitored by caspase-3 was observed after day 15 with irinotecan treatment.	Irinotecan	74-84	caspase 3	Mus musculus	33-42	
16095811-4	2005	In vitro, SN38, the active metabolite of CPT-11, induced activation of NF-kB, the production of intracellular reactive oxygen species, the activation of caspase-3, and apoptosis in colon26 cells.	Irinotecan	41-47	caspase 3	Mus musculus	153-162	
18425325-6	2008	Intraperitoneal CPT-11 injections induced specific TUNEL-positive cells and cell death with cleaved caspase 3 expression among large ovarian follicular granulosa cells.	Irinotecan	16-22	caspase 3	Mus musculus	100-109	
22469241-7	2012	For irinotecan-, oxaliplatin-, and bevacizumab-treated tumors, a significant correlation was established between the radiotracer uptake and caspase-3 immunostaining (r  =  .8, p < .05; r  =  .9, p < .001; r  =  .9, p < .001, respectively).	Irinotecan	4-14	caspase 3	Mus musculus	140-149