PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19885570-7 2009 The combination of safingol/irinotecan at 1:1 molar ratio was found to be additive in HT-29 cells (CI=0.94) and synergistic in LS-174T cells (CI=0.68), and resulted in concentration- and time-dependent down-regulation of p-PKC and p-MARCKS. Irinotecan 28-38 myristoylated alanine rich protein kinase C substrate Homo sapiens 233-239