PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33957564-0	2021	Epac-1/Rap-1 signaling pathway orchestrates the reno-therapeutic effect of ticagrelor against renal ischemia/reperfusion model.	Ticagrelor	75-85	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	0-6	
33957564-7	2021	On the molecular level, ticagrelor enhanced renal Epac-1 mRNA expression, Rap-1 activation (Rap-1-GTP) and SOCS-3 level.	Ticagrelor	24-34	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	50-56	
33957564-11	2021	In conclusion, ticagrelor reno-therapeutic effect is partly mediated through modulating the Epac-1/Rap-1-GTP, AKT/Nrf-2/HO-1 and JAK-2/STAT-3/SOCS-3 trajectories, pathways that integrate to afford novel explanations to its anti-inflammatory, anti-oxidant, and anti-apoptotic potentials.	Ticagrelor	15-25	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	92-98