PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11408559-0 2001 Cytosolic phospholipase A2 activation by the p38 kinase inhibitor SB203580 in rabbit aortic smooth muscle cells. SB 203580 66-74 cytosolic phospholipase A2 Oryctolagus cuniculus 0-26 11408559-2 2001 Here we report that SB203580, which blocked p38 kinase activation elicited by anisomycin, increased the phosphorylation and activity of cytosolic phospholipase A2 (cPLA2) and arachidonic acid (AA) release in quiescent vascular smooth muscle cells from rabbit aortae. SB 203580 20-28 cytosolic phospholipase A2 Oryctolagus cuniculus 136-162 11408559-2 2001 Here we report that SB203580, which blocked p38 kinase activation elicited by anisomycin, increased the phosphorylation and activity of cytosolic phospholipase A2 (cPLA2) and arachidonic acid (AA) release in quiescent vascular smooth muscle cells from rabbit aortae. SB 203580 20-28 cytosolic phospholipase A2 Oryctolagus cuniculus 164-169 11408559-4 2001 The increase in CaMKII activity and cPLA2 phosphorylation caused by SB203580 was attenuated by CaMKII inhibitor KN-93, indicating involvement of CaMKII in cPLA2 phosphorylation by this compound. SB 203580 68-76 cytosolic phospholipase A2 Oryctolagus cuniculus 36-41 11408559-4 2001 The increase in CaMKII activity and cPLA2 phosphorylation caused by SB203580 was attenuated by CaMKII inhibitor KN-93, indicating involvement of CaMKII in cPLA2 phosphorylation by this compound. SB 203580 68-76 cytosolic phospholipase A2 Oryctolagus cuniculus 155-160 11408559-6 2001 SB203580-induced cPLA2 phosphorylation was inhibited by depletion of Ca2+ from the medium, by the voltage-operated Ca2+ channel blocker nifedipine, and by the calmodulin inhibitor W-7. SB 203580 0-8 cytosolic phospholipase A2 Oryctolagus cuniculus 17-22 11408559-7 2001 cPLA2 translocation from cytoplasm to the nuclear envelope caused by SB203580 was also inhibited in the absence of extracellular Ca2+. SB 203580 69-77 cytosolic phospholipase A2 Oryctolagus cuniculus 0-5 11408559-9 2001 These data suggest that SB203580 not only inhibits p38 kinase activity but also increases Ca2+ influx through voltage-sensitive Ca2+ channels, which promotes cPLA2 translocation to the nuclear envelope, and by interacting with calmodulin, activates CaMKII and cPLA2 and releases AA. SB 203580 24-32 cytosolic phospholipase A2 Oryctolagus cuniculus 158-163 11408559-9 2001 These data suggest that SB203580 not only inhibits p38 kinase activity but also increases Ca2+ influx through voltage-sensitive Ca2+ channels, which promotes cPLA2 translocation to the nuclear envelope, and by interacting with calmodulin, activates CaMKII and cPLA2 and releases AA. SB 203580 24-32 cytosolic phospholipase A2 Oryctolagus cuniculus 260-265