PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27846303-7 2016 P38MAPK inhibitor SB203580, but not inhibitors of EGFR (erlotinib), ERK (FR180204) and JNK (SP600125), suppressed AF-induced phosphorylation of EGFR/p38MAPK/MAPKAPK2/Hsp27. SB 203580 18-26 heat shock protein family B (small) member 1 Homo sapiens 166-171 27451881-9 2016 TNF-alpha-induced COX-2 expression, Hsp27 phosphorylation, and MFB migration were all significantly inhibited by the P38 MAPK inhibitor SB203580 (P < 0.05). SB 203580 136-144 heat shock protein family B (small) member 1 Homo sapiens 36-41 26877709-9 2016 Furthermore, melatonin increased P38 activity, and P38 inhibitor SB203580 inhibited melatonin-induced PI3K/Akt, HSP27 activation and accelerated cell apoptosis. SB 203580 65-73 heat shock protein family B (small) member 1 Homo sapiens 112-117 21983652-8 2011 Increases in HSP27 phosphorylation were suppressed by pretreating cells with SB203580 or SP600125, which are inhibitors of p38 MAPK or JNK, respectively. SB 203580 77-85 heat shock protein family B (small) member 1 Homo sapiens 13-18 25364415-4 2014 Treatment with a selective inhibitor, p38 mitogen-activated protein kinase (MAPK; SB203580), caused the dose-dependent suppression of HSP27 phosphorylation, which was upregulated by 5-FU, reducing the half maximal inhibitory concentration values of 5-FU in the HCT116 and HCT15 cells. SB 203580 82-90 heat shock protein family B (small) member 1 Homo sapiens 134-139 23112078-7 2013 p38 activation and phosphorylated HSP27 levels generally correlate well with cellular morphology, and treatment with the p38 inhibitor SB203580 effects cellular morphology only in strains with enlarged cells and phosphorylated HSP27. SB 203580 135-143 heat shock protein family B (small) member 1 Homo sapiens 227-232 22903412-5 2012 The results showed that, after blocking the activation of Hsp27 by SB203580 or KRIBB3, 200 muM t-AUCB significantly induces apoptosis and increases caspase-3 activities in U251 and U87 cells. SB 203580 67-75 heat shock protein family B (small) member 1 Homo sapiens 58-63 22490108-11 2012 Arecoline-induced HSP27 expression was downregulated by EGCG, NS398, NAC, quercetin, PD98059, and SB203580. SB 203580 98-106 heat shock protein family B (small) member 1 Homo sapiens 18-23 22664592-5 2012 Furthermore, after P79350 or combined SB203580 and PUGNAc treatment, increased nuclear import of HSP27-WT and HSP27-3D implied that the entry of HSP27 into the nucleus was not only correlated with phosphorylation, but also with O-GlcNAc glycosylation. SB 203580 50-58 heat shock protein family B (small) member 1 Homo sapiens 109-117 22664592-5 2012 Furthermore, after P79350 or combined SB203580 and PUGNAc treatment, increased nuclear import of HSP27-WT and HSP27-3D implied that the entry of HSP27 into the nucleus was not only correlated with phosphorylation, but also with O-GlcNAc glycosylation. SB 203580 50-58 heat shock protein family B (small) member 1 Homo sapiens 109-114 21081267-4 2011 Expression and phosphorylation of hsp27 was inhibited in these models by siRNA and SB203580, a specific inhibitor of p38-MAPK, respectively. SB 203580 83-91 heat shock protein family B (small) member 1 Homo sapiens 34-39 20730553-4 2011 Low pH culture conditions were found to dramatically prolong cell survival after doxorubicin treatment, an effect that was in part reversed by co-incubation with the specific p38 mitoge-activated protein kinase (MAP kinase) inhibitor SB203580, only mildly inhibited by blockade of the multi-drug resistance 1 (MDR1) transporter, but completely abolished by siRNA-mediated knockdown of the heat shock protein 27 (HSP27). SB 203580 234-242 heat shock protein family B (small) member 1 Homo sapiens 389-410 20730553-4 2011 Low pH culture conditions were found to dramatically prolong cell survival after doxorubicin treatment, an effect that was in part reversed by co-incubation with the specific p38 mitoge-activated protein kinase (MAP kinase) inhibitor SB203580, only mildly inhibited by blockade of the multi-drug resistance 1 (MDR1) transporter, but completely abolished by siRNA-mediated knockdown of the heat shock protein 27 (HSP27). SB 203580 234-242 heat shock protein family B (small) member 1 Homo sapiens 412-417 21467633-7 2011 Inhibiting p38 MAPK with SB203580 blocked TGF-beta1-induced Hsp27 activation and cell migration. SB 203580 25-33 heat shock protein family B (small) member 1 Homo sapiens 60-65 20644550-6 2010 These effects were abolished by pretreatment with the p38 MAPK inhibitor SB203580 10 mumol/L, indicating that the Ang II-induced endothelial barrier dysfunction was via activation of the p38 MAPK/HSP27 pathway. SB 203580 73-81 heat shock protein family B (small) member 1 Homo sapiens 196-201 15896702-6 2005 The combination of Akt inhibitor and SB203580, a p38 MAP kinase inhibitor, completely suppressed the AVP-induced phosphorylation of HSP27. SB 203580 37-45 heat shock protein family B (small) member 1 Homo sapiens 132-137 20332631-6 2010 The inhibition of p38MAPK by SB203580 blocked the ATP depletion to induce HSP27 phosphorylation and actin polymerization. SB 203580 29-37 heat shock protein family B (small) member 1 Homo sapiens 74-79 19513626-10 2009 The expression of HSP27 could be down-regulated with the pretreatment of SB203580 and PD98059 jointly. SB 203580 73-81 heat shock protein family B (small) member 1 Homo sapiens 18-23 18757417-9 2008 Blockade of the p38 MAPK pathway by SB203580 remarkably inhibited the phosphorylation of HSP27 induced by 5-FU and decreased the induction of Egr-1 and TSP-1 by 5-FU in KM12C cells. SB 203580 36-44 heat shock protein family B (small) member 1 Homo sapiens 89-94 18440775-2 2008 VEGF-induced HSP27 phosphorylation at serines 15, 78 and 82, but whereas HSP27 phosphorylation induced by H2O2 and TNFalpha was completely blocked by the p38 kinase inhibitor, SB203580, VEGF-stimulated serine 82 phosphorylation was resistant to SB203580 and small interfering(si)RNA-mediated knockdown of p38 kinase and MAPKAPK2. SB 203580 176-184 heat shock protein family B (small) member 1 Homo sapiens 13-18 18440775-2 2008 VEGF-induced HSP27 phosphorylation at serines 15, 78 and 82, but whereas HSP27 phosphorylation induced by H2O2 and TNFalpha was completely blocked by the p38 kinase inhibitor, SB203580, VEGF-stimulated serine 82 phosphorylation was resistant to SB203580 and small interfering(si)RNA-mediated knockdown of p38 kinase and MAPKAPK2. SB 203580 176-184 heat shock protein family B (small) member 1 Homo sapiens 73-78 17697330-5 2007 The extent of Hsp27 phosphorylation at its Ser15, Ser78 and Ser82 residues were further evaluated with site-specific antibodies in tumor samples by tissue lysate array- and tissue microarray-based analyses, and in the BT474 breast cancer cell line treated with heregulin alpha1 (HRG alpha1) or the p38 MAPK inhibitor, SB203580. SB 203580 318-326 heat shock protein family B (small) member 1 Homo sapiens 14-19 17185631-7 2007 The p38 inhibitor SB203580, but not the MEK-1 inhibitor PD98059, blocked Hsp27 induction by fMLP. SB 203580 18-26 heat shock protein family B (small) member 1 Homo sapiens 73-78 16407830-5 2006 After transient transfection, wild-type MAPKAPK2 and HSP27 both increased TGFbeta-mediated matrix metalloproteinase type 2 (MMP-2) activity, as well as cell invasion, which in turn was inhibited by SB203580, an inhibitor of p38 MAP kinase. SB 203580 198-206 heat shock protein family B (small) member 1 Homo sapiens 53-58 20209605-6 2010 Furthermore, suppression of HSP27 expression by small interfering RNA or the p38 MAPK pathway-specific inhibitor SB203580 decreases the migration of HCC cells overexpressing miR-17-5p but does not reduce their proliferation. SB 203580 113-121 heat shock protein family B (small) member 1 Homo sapiens 28-33 18552392-11 2008 Pretreatment of cells with SB203580, an inhibitor for p38MAP kinase, reduced the H(2)O(2)- and TGF-beta2-stimulated Hsp27 expression, whereas pretreatment with PD98059 and U0126, specific inhibitors of ERK1/2, and SP600125, a specific c-Jun N-terminal kinase inhibitor, had no effects. SB 203580 27-35 heat shock protein family B (small) member 1 Homo sapiens 116-121 17640620-6 2007 SB203580 or p38MAPK siRNA blocked these phenomena, indicating that Hsp27 phosphorylation and translocation from cytosol to membrane were mediated by p38MAPK. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 67-72 17673262-6 2007 SB203580, an inhibitor of p38 MAPK, suppressed the TPA-induced HSP27 phosphorylation. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 63-68 16790501-10 2006 The p38 MAPK inhibitor (SB-203580) and p38 MAPK siRNA blocked Hsp27 and Hsp70 mRNA induction, suggesting a role for MAPKs in the HEMEC heat shock response. SB 203580 24-33 heat shock protein family B (small) member 1 Homo sapiens 62-67 16114012-5 2006 When cells were pre-treated with SB 203580, which inhibits HSP27 phosphorylation through inhibition of p38 MAP kinase activation, the arsenite-induced reduction of UVB-induced apoptosis was partially reversed. SB 203580 33-42 heat shock protein family B (small) member 1 Homo sapiens 59-64 15864808-3 2005 Treatment targeting the ER with tunicamycin or thapsigargin induced the phosphorylation of Hsp27 but not of alphaB-crystallin in U373 MG cells, increase being observed after 2-10 h and decline at 24 h. Similar phosphorylation of Hsp27 by ER stress was also observed with U251 MG and HeLa but not in COS cells and could be blocked using SB203580, an inhibitor of p38 MAP kinase. SB 203580 336-344 heat shock protein family B (small) member 1 Homo sapiens 91-96 15848222-4 2005 SB203580, a p38 MAP kinase inhibitor, significantly suppressed the thrombin-induced phosphorylation of Akt and the Akt inhibitor suppressed the phosphorylation of HSP27. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 163-168 15317596-7 2004 Although MG132 had little effect on the colocalization of eIF4E and eIF4GI, it promoted the SB203580-sensitive association of eIF4GI and hsp25, an effect not observed with alphaB-crystallin. SB 203580 92-100 heat shock protein family B (small) member 1 Homo sapiens 137-142 15774115-8 2005 The expression of HSP(27) was down-regulated with the pretreatment of SB 203580 compared with that in the H2O2 group (P < 0.01). SB 203580 70-79 heat shock protein family B (small) member 1 Homo sapiens 18-25 12181122-8 2002 SB-203580 reduced the thrombin-increased level of HSP27 mRNA. SB 203580 0-9 heat shock protein family B (small) member 1 Homo sapiens 50-55 15258903-4 2004 The AVP-induced phosphorylation of HSP27 was attenuated by SB203580 and PD169316, inhibitors of p38 mitogen-activated protein (MAP) kinase, but not by PD98059, a MEK inhibitor. SB 203580 59-67 heat shock protein family B (small) member 1 Homo sapiens 35-40 12847121-10 2003 Our immunohistochemical studies showed that immune complexes of phosphorylated forms of both p38-MAPK and HSP27 were strongly enhanced by 30 micro mol l(-1) H(2)O(2) in the perinuclear region as well as dispersedly in the cytoplasm of ventricular cells and that SB203580 abolished this phosphorylation. SB 203580 262-270 heat shock protein family B (small) member 1 Homo sapiens 106-111 15194498-10 2004 The p38 MAPK inhibitor, SB203580, inhibited effectively phosphorylation of HSP-27, CREB, and eIF4E in SARS-CoV-infected cells. SB 203580 24-32 heat shock protein family B (small) member 1 Homo sapiens 75-81 12781867-4 2003 These data show that while the arsenite-induced increase in the phosphorylation of eIF4E and hsp25 was sensitive to SB203580 in cells expressing WT-SAPK2a, these responses to SB203580 were abrogated in cells expressing DR-SAPK2a. SB 203580 116-124 heat shock protein family B (small) member 1 Homo sapiens 93-98 12181122-11 2002 Thrombin induced the phosphorylation of HSP27 and the phosphorylation was suppressed by SB-203580. SB 203580 88-97 heat shock protein family B (small) member 1 Homo sapiens 40-45 9369943-6 1997 SB 203580 specifically inhibits activation of p38RK as judged by MAPKAP kinase 2 activity against the substrate Hsp27 and also blocks Hsp27 phosphorylation in the cells. SB 203580 0-9 heat shock protein family B (small) member 1 Homo sapiens 112-117 11912188-5 2002 Phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38 MAPK and ERK was markedly increased by the heat shock, and SB203580 (a p38 MAPK kinase inhibitor) and/or PD098059 (a MEK inhibitor) inhibited the phosphorylation of HSP25, indicating that p38 MAPK and ERK are upstream regulators of HSP25 phosphorylation in the heat shock condition. SB 203580 132-140 heat shock protein family B (small) member 1 Homo sapiens 238-243 11912188-5 2002 Phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38 MAPK and ERK was markedly increased by the heat shock, and SB203580 (a p38 MAPK kinase inhibitor) and/or PD098059 (a MEK inhibitor) inhibited the phosphorylation of HSP25, indicating that p38 MAPK and ERK are upstream regulators of HSP25 phosphorylation in the heat shock condition. SB 203580 132-140 heat shock protein family B (small) member 1 Homo sapiens 305-310 11912188-7 2002 Heat shock caused disruption of the actin filament and cell death when phosphorylation of HSP25 was inhibited by SB203580 and/or PD098059. SB 203580 113-121 heat shock protein family B (small) member 1 Homo sapiens 90-95 12076339-4 2002 Mobile phone exposure caused a transient increase in phosphorylation of hsp27, an effect which was prevented by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase (p38MAPK). SB 203580 112-120 heat shock protein family B (small) member 1 Homo sapiens 72-77 10843887-6 2000 SB-203580 reduced muscle contraction and inhibited p38 MAP kinase and HSP27 phosphorylation but had no effect on ERK MAP kinase and caldesmon phosphorylation. SB 203580 0-9 heat shock protein family B (small) member 1 Homo sapiens 70-75 10679516-6 2000 SB203580 and PD169316, specific inhibitors of p38 MAP kinase, suppressed the AVP-induced accumulation of HSP27. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 105-110 10679516-7 2000 12-O-tetradecanoylphorbol 13-acetate, an activator of protein kinase C, induced accumulation of HSP27 and was not inhibited by PD98059 but was inhibited by SB203580. SB 203580 156-164 heat shock protein family B (small) member 1 Homo sapiens 96-101 10679516-9 2000 SB203580 and PD169316 suppressed the AVP-increased levels in mRNA for HSP27. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 70-75 10600754-7 1999 In contrast, overexpression of nonphosphorylatable mutants, 3A- and 3G-HSP27, or inhibition of phosphorylation of HSP27 by preincubation of wt-HSP27 transfected cells with SB-203580 did not protect the actin cytoskeleton. SB 203580 172-181 heat shock protein family B (small) member 1 Homo sapiens 114-119 10600754-7 1999 In contrast, overexpression of nonphosphorylatable mutants, 3A- and 3G-HSP27, or inhibition of phosphorylation of HSP27 by preincubation of wt-HSP27 transfected cells with SB-203580 did not protect the actin cytoskeleton. SB 203580 172-181 heat shock protein family B (small) member 1 Homo sapiens 114-119 10413591-7 1999 In contrast, SB203580, an inhibitor of p38 MAP kinase, reduced sphingosine 1-phosphate-induced HSP27 induction. SB 203580 13-21 heat shock protein family B (small) member 1 Homo sapiens 95-100 10413591-8 1999 SB203580 reduced the levels of mRNA for HSP27 induced by sphingosine 1-phosphate. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 40-45 12112005-7 2002 SB203580 and PD169316, inhibitors of p38 MAP kinase, suppressed the HSP27 accumulation by dexamethasone. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 68-73 12112005-8 2002 In addition, SB203580 reduced the dexamethasone-stimulated increase of the mRNA levels for HSP27. SB 203580 13-21 heat shock protein family B (small) member 1 Homo sapiens 91-96 11781079-7 2002 Phosphorylation of p38MAPK was increased by Pb2+ and the effect of Pb2+ on Hsp27 phosphorylation was blocked by the p38MAPK inhibitor SB203580 (1 microM). SB 203580 134-142 heat shock protein family B (small) member 1 Homo sapiens 75-80 11034403-5 2000 Although exogenous hsp27 stimulation activated all three monocyte mitogen-activated protein kinase pathways (extracellular signal-related kinase (ERK) 1/2, c-Jun N-terminal kinase, and p38), only p38 activation was sustained and required for hsp27 induction of monocyte IL-10, while both ERK 1/2 and p38 activation were required for induction of TNF-alpha when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059. SB 203580 385-393 heat shock protein family B (small) member 1 Homo sapiens 19-24 9369943-6 1997 SB 203580 specifically inhibits activation of p38RK as judged by MAPKAP kinase 2 activity against the substrate Hsp27 and also blocks Hsp27 phosphorylation in the cells. SB 203580 0-9 heat shock protein family B (small) member 1 Homo sapiens 134-139 9048659-6 1997 Moreover, fibroblasts acquired an endothelium-like SB203580-sensitive actin response when HSP27 concentration was increased by gene transfection to the same high level as found in HUVECs. SB 203580 51-59 heat shock protein family B (small) member 1 Homo sapiens 90-95 9393975-7 1997 Inhibition of p38 activity by the specific inhibitor SB203580 led to an inhibition of HSP27 phosphorylation, actin reorganization and cell migration. SB 203580 53-61 heat shock protein family B (small) member 1 Homo sapiens 86-91 9250394-0 1997 The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27. SB 203580 29-37 heat shock protein family B (small) member 1 Homo sapiens 115-120 9250394-5 1997 As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation. SB 203580 63-72 heat shock protein family B (small) member 1 Homo sapiens 25-30 9250394-5 1997 As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation. SB 203580 63-72 heat shock protein family B (small) member 1 Homo sapiens 208-213 8617238-5 1996 Pretreatment of cells with the highly specific p38 MAP kinase inhibitor SB203580 completely blocked this TNF-induced activation of MAPKAP kinase-2 and hsp27 phosphorylation. SB 203580 72-80 heat shock protein family B (small) member 1 Homo sapiens 151-156 33061803-7 2020 The activation of p38-MAPK/HSP27 induced by the p38-MAPK activator Anisomycin enhanced the apoptosis of lung SCC cells, while the ROS inhibitor N-acetyl-L-cysteine (NAC) and the p38-MAPK inhibitor SB203580 both attenuated dioscin-mediated cell apoptosis. SB 203580 197-205 heat shock protein family B (small) member 1 Homo sapiens 27-32 33119719-11 2020 SB203580, a specific inhibitor of p38 MAPK, attenuated the platelet aggregation, the phosphorylation of p38 MAPK and HSP27, the PDGF-AB secretion, the sCD40L release and the phosphorylated-HSP27 release induced by the simultaneous stimulation with collagen and CXCL12. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 117-122 33119719-11 2020 SB203580, a specific inhibitor of p38 MAPK, attenuated the platelet aggregation, the phosphorylation of p38 MAPK and HSP27, the PDGF-AB secretion, the sCD40L release and the phosphorylated-HSP27 release induced by the simultaneous stimulation with collagen and CXCL12. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 189-194 7750577-3 1995 We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM), suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of heat shock protein (HSP) 27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo. SB 203580 41-50 heat shock protein family B (small) member 1 Homo sapiens 175-202 30212812-9 2018 SB203580, a p38 MAPK inhibitor, but not SP600125, a JNK inhibitor, suppressed the release of phosphorylated-HSP27 in addition to HSP27 phosphorylation. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 108-113 30212812-9 2018 SB203580, a p38 MAPK inhibitor, but not SP600125, a JNK inhibitor, suppressed the release of phosphorylated-HSP27 in addition to HSP27 phosphorylation. SB 203580 0-8 heat shock protein family B (small) member 1 Homo sapiens 129-134 28671960-6 2017 The p38 inhibitor SB203580 prevented phosphorylation of HSP27 and ameliorated morphological changes. SB 203580 18-26 heat shock protein family B (small) member 1 Homo sapiens 56-61