PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22545124-8 2012 Western Blotting results showed that stimulation of NSPCs with Sal B enhanced the phosphorylation of Akt, and Ly294002 abolished this effect, confirming the role of Akt in Sal B mediated proliferation of NSPCs. salvianolic acid B 63-68 AKT serine/threonine kinase 1 Rattus norvegicus 101-104 22545124-8 2012 Western Blotting results showed that stimulation of NSPCs with Sal B enhanced the phosphorylation of Akt, and Ly294002 abolished this effect, confirming the role of Akt in Sal B mediated proliferation of NSPCs. salvianolic acid B 172-177 AKT serine/threonine kinase 1 Rattus norvegicus 165-168 22545124-12 2012 SIGNIFICANCE: Sal B could maintain the NSPCs self-renew and promote proliferation, which was mediated by PI3K/Akt signal pathway. salvianolic acid B 14-19 AKT serine/threonine kinase 1 Rattus norvegicus 110-113 18091994-0 2007 Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 18091994-7 2007 On the other hand, blockage of the PI3K/Akt pathway abrogated the protective effect conferred by Sal B and potentated H(2)O(2)-induced apoptosis, suggesting that Sal B prevents H(2)O(2)-induced apoptosis predominantly through the PI3K/Akt (upstream of ERK) pathway. salvianolic acid B 97-102 AKT serine/threonine kinase 1 Rattus norvegicus 40-43 18091994-7 2007 On the other hand, blockage of the PI3K/Akt pathway abrogated the protective effect conferred by Sal B and potentated H(2)O(2)-induced apoptosis, suggesting that Sal B prevents H(2)O(2)-induced apoptosis predominantly through the PI3K/Akt (upstream of ERK) pathway. salvianolic acid B 162-167 AKT serine/threonine kinase 1 Rattus norvegicus 40-43 18091994-7 2007 On the other hand, blockage of the PI3K/Akt pathway abrogated the protective effect conferred by Sal B and potentated H(2)O(2)-induced apoptosis, suggesting that Sal B prevents H(2)O(2)-induced apoptosis predominantly through the PI3K/Akt (upstream of ERK) pathway. salvianolic acid B 162-167 AKT serine/threonine kinase 1 Rattus norvegicus 235-238 18091994-8 2007 SIGNIFICANCE: Our findings provide the first evidence that H(2)O(2) induces rCMECs apoptosis via the PI3K/MEK/ERK pathway and that Sal B protects rCMECs against H(2)O(2)-induced apoptosis through the PI3K/Akt/Raf/MEK/ERK pathway. salvianolic acid B 131-136 AKT serine/threonine kinase 1 Rattus norvegicus 205-208 34364877-0 2021 Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3beta signaling and preserving mitochondrial function. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 93-96 34364877-7 2021 Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B. salvianolic acid B 17-22 AKT serine/threonine kinase 1 Rattus norvegicus 74-77 34364877-7 2021 Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B. salvianolic acid B 202-207 AKT serine/threonine kinase 1 Rattus norvegicus 74-77 34364877-9 2021 Together, our results demonstrated that the damage of intestinal epithelial cells in in vitro and in vivo models were both attenuated by Sal B treatment, and such antioxidant activity might very possibly be attributed to the activation of Akt/GSK3beta signaling. salvianolic acid B 137-142 AKT serine/threonine kinase 1 Rattus norvegicus 239-242 31603005-11 2019 The protective function of Sal-B was enabled through activating PI3K/AKT and MEK/ERK pathways. salvianolic acid B 27-32 AKT serine/threonine kinase 1 Rattus norvegicus 69-72 31853618-0 2020 Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 161-164 31853618-6 2020 In the current study, Sal B significantly ameliorated myocardial I/R injury in a dose-dependent manner, ameliorated cardiac function, reduced myocardial infarction size, decreased myocardial injury marker expression, decreased inflammatory responses, reduced apoptosis, activated PI3K/Akt expression and inhibited HMGB1 expression. salvianolic acid B 22-27 AKT serine/threonine kinase 1 Rattus norvegicus 285-288 31853618-8 2020 Overall, the present study indicated that Sal B attenuated myocardial I/R injury by activating PI3K/Akt and inhibiting the release of HMGB1 in rats. salvianolic acid B 42-47 AKT serine/threonine kinase 1 Rattus norvegicus 100-103 31603005-12 2019 These findings delineated that Sal-B protected PC-12 cells against H2O2-caused injury through ascending miR-26a via initiating PI3K/AKT and MEK/ERK pathways. salvianolic acid B 31-36 AKT serine/threonine kinase 1 Rattus norvegicus 132-135 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 AKT serine/threonine kinase 1 Rattus norvegicus 178-181 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 AKT serine/threonine kinase 1 Rattus norvegicus 178-181 31112902-0 2019 Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling. salvianolic acid B 45-63 AKT serine/threonine kinase 1 Rattus norvegicus 103-106 31112902-15 2019 Thus, these data suggest that Sal B has anticonvulsant and anti-apoptotic effects in a PTZ-induced seizure model through activation of the AKT/CREB/BDNF signaling pathways. salvianolic acid B 30-35 AKT serine/threonine kinase 1 Rattus norvegicus 139-142 28513773-0 2017 Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K/Akt signaling pathway. salvianolic acid B 52-70 AKT serine/threonine kinase 1 Rattus norvegicus 134-137 28992623-0 2017 Salvianolic Acid B Ameliorates Cognitive Deficits Through IGF-1/Akt Pathway in Rats with Vascular Dementia. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 64-67 27382429-0 2016 Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 101-104 27382429-10 2016 Thus, our results demonstrate that, due to its antioxidant properties, SB has the potential to effectively prevent CI-AKI via the PI3K/Akt/Nrf2 pathway. salvianolic acid B 71-73 AKT serine/threonine kinase 1 Rattus norvegicus 135-138