PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 44-62 vascular endothelial growth factor A Rattus norvegicus 308-312 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 64-69 vascular endothelial growth factor A Rattus norvegicus 308-312 30193865-10 2018 In the PPE-induced model, Sal-B reduced induction of lung"s matrix metalloproteinase (MMP)-9 and MMP-2 activities by 59 and 94%, respectively, and restored pSTAT3 and VEGF expressions to the healthy lung levels, while leaving neutrophil accumulation unchecked [myeloperoxidase (MPO) activity]. salvianolic acid B 26-31 vascular endothelial growth factor A Rattus norvegicus 167-171 30193865-12 2018 These results provide an in vivo proof-of-concept for Sal-B as one of the first anti-emphysema agents enabling reversal of alveolar structural destruction and loss via local lung treatment by virtue of its STAT3 activation and VEGF stimulation. salvianolic acid B 54-59 vascular endothelial growth factor A Rattus norvegicus 227-231 30291890-0 2018 Salvianolic acid B as an anti-emphysema agent I: In vitro stimulation of lung cell proliferation and migration, and protection against lung cell death, and in vivo lung STAT3 activation and VEGF elevation. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 190-194 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 27-45 vascular endothelial growth factor A Rattus norvegicus 175-179 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 47-52 vascular endothelial growth factor A Rattus norvegicus 175-179 30291890-9 2018 In rats, Sal-B at 0.2 mg/kg enabled 1.9 and 1.5-fold increased STAT3 phosphorylation and VEGF elevation in the lungs, respectively, while causing no functional and morphological abnormalities. salvianolic acid B 9-14 vascular endothelial growth factor A Rattus norvegicus 89-93 30291890-10 2018 Hence, Sal-B was projected to be a new class of anti-emphysema agent capable of reversing alveolar structural destruction/loss via JAK2/STAT3/VEGF-dependent stimulation of lung cell proliferation and migration, and inhibition of induced lung cell death. salvianolic acid B 7-12 vascular endothelial growth factor A Rattus norvegicus 142-146 29257241-0 2018 Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 123-127 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 vascular endothelial growth factor A Rattus norvegicus 151-185 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 vascular endothelial growth factor A Rattus norvegicus 187-191 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 vascular endothelial growth factor A Rattus norvegicus 197-201 27852325-8 2016 The extent of the epidural scar, the regeneration of the vasculature and the expression levels of VEGF suggested better outcomes in the Sal B-treated groups. salvianolic acid B 136-141 vascular endothelial growth factor A Rattus norvegicus 98-102 27497919-0 2016 Salvianolic acid B improves the disruption of high glucose-mediated brain microvascular endothelial cells via the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 129-133 27497919-0 2016 Salvianolic acid B improves the disruption of high glucose-mediated brain microvascular endothelial cells via the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 147-151 27497919-3 2016 And the increase of reactive oxidative species (ROS) production, the upregulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein induced by high glucose were antagonized by Sal B. salvianolic acid B 229-234 vascular endothelial growth factor A Rattus norvegicus 135-169 27497919-3 2016 And the increase of reactive oxidative species (ROS) production, the upregulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein induced by high glucose were antagonized by Sal B. salvianolic acid B 229-234 vascular endothelial growth factor A Rattus norvegicus 171-175 27497919-6 2016 This led to the conclusion that Sal B-mediated improvement of blood-brain barrier dysfunction induced by high-glucose is related to the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 32-37 vascular endothelial growth factor A Rattus norvegicus 151-155 27497919-6 2016 This led to the conclusion that Sal B-mediated improvement of blood-brain barrier dysfunction induced by high-glucose is related to the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 32-37 vascular endothelial growth factor A Rattus norvegicus 169-173 27139338-9 2016 Sal B inhibited the expression of Bax, cleaved caspase-9 and cleaved PARP, while promoted the expression of Bcl-2, LC3-II, Beclin1 and VEGF. salvianolic acid B 0-5 vascular endothelial growth factor A Rattus norvegicus 135-139 25294002-12 2014 The expression of VEGF and inflammatory factors in operative sites also suggested better results in the Sal B group than the other two groups. salvianolic acid B 104-109 vascular endothelial growth factor A Rattus norvegicus 18-22 18500511-7 2008 The additional beneficial effects of Sal B relative to benazpril, augmenting VEGF expression and promoting angiogenesis, may result in improved myocardial microcirculation. salvianolic acid B 37-42 vascular endothelial growth factor A Rattus norvegicus 77-81 18622062-8 2008 However, Sal B enforced some different modality than benazepril, which might improve myocardial microcirculation by augmenting VEGF expression and promoting angiogenesis besides similar effects to benazepril. salvianolic acid B 9-14 vascular endothelial growth factor A Rattus norvegicus 127-131 34748867-14 2022 The results of PLSR and CCA revealed that the contents of puerarin, daidzin, salvianolic acid B and ginsenoside Rb1 were inversely correlated with the expression of VEGF and HIF-1alpha. salvianolic acid B 77-95 vascular endothelial growth factor A Rattus norvegicus 165-169 34748867-16 2022 The results of intervention on primary culture retinal Muller cells showed that puerarin, daidzin, salvianolic acid B, and ginsenoside Rb1 can significantly inhibit the expression of VEGF and HIF-1alpha. salvianolic acid B 99-117 vascular endothelial growth factor A Rattus norvegicus 183-187