PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16713603-0	2006	Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor-alpha (TNF-alpha)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase-derived reactive oxygen species.	salvianolic acid B	0-18	matrix metallopeptidase 2	Homo sapiens	101-106	
33899116-11	2021	Similarly, Sal B significantly decreased TGF-beta1-induced TbetaR-I, TbetaR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs.	salvianolic acid B	11-16	matrix metallopeptidase 2	Homo sapiens	91-96	
19216858-6	2009	The research was designed to explore the inhibitory effects of Sal B on MMP-1, MMP-2 and MMP-9 activities.	salvianolic acid B	63-68	matrix metallopeptidase 2	Homo sapiens	79-84	
19216858-7	2009	METHODS: Pure human interstitial collagenase (MMP-1) or gelatinase A (MMP-2) was activated by p-aminophenylmercuric acetate (APMA), and was incubated with Sal B for 1 h. The activities were observed by quenched fluorescent substrate.	salvianolic acid B	155-160	matrix metallopeptidase 2	Homo sapiens	70-75	
19216858-10	2009	RESULTS: Sal B dose-dependently inhibited the human MMP-1 and MMP-2 activities in the range of 0.002 4 to 0.3 g/L, with 50% inhibiting concentration (IC(50)) of (0.090<0.015) g/L and (0.080<0.005) g/L respectively.	salvianolic acid B	9-14	matrix metallopeptidase 2	Homo sapiens	62-67	
18591779-5	2008	These results indicated that Sal B could inhibit high glucose-induced mesangial cells proliferation and extracellular matrix production in a dose-dependent manner, partially through modulating the cell-cycle progress and MMP-2 and MMP-9 activities via suppressing NF-kappaB activation, suggesting that Sal B may be a promising agent for treating diabetic nephropathy.	salvianolic acid B	29-34	matrix metallopeptidase 2	Homo sapiens	221-226	
16924668-4	2007	Sal B significantly attenuated upregulations of both MMPs as well as the LPS-induced cell migration through the inactivation of MMP-2 and MMP-9 protein synthesis as well as the downregulation of the extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun NH(2)-terminal kinase (JNK).	salvianolic acid B	0-5	matrix metallopeptidase 2	Homo sapiens	53-57	
16924668-4	2007	Sal B significantly attenuated upregulations of both MMPs as well as the LPS-induced cell migration through the inactivation of MMP-2 and MMP-9 protein synthesis as well as the downregulation of the extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun NH(2)-terminal kinase (JNK).	salvianolic acid B	0-5	matrix metallopeptidase 2	Homo sapiens	128-133	
16713603-3	2006	In the present study, the effects of a potent water-soluble antioxidant, salvianolic acid B (SalB), derived from a Chinese herb, Salvia miltiorrhiza, on the expression of MMP-2 by TNF-alpha-treated human aortic smooth muscle cells (HASMCs) were investigated.	salvianolic acid B	73-91	matrix metallopeptidase 2	Homo sapiens	171-176	
16713603-3	2006	In the present study, the effects of a potent water-soluble antioxidant, salvianolic acid B (SalB), derived from a Chinese herb, Salvia miltiorrhiza, on the expression of MMP-2 by TNF-alpha-treated human aortic smooth muscle cells (HASMCs) were investigated.	salvianolic acid B	93-97	matrix metallopeptidase 2	Homo sapiens	171-176	
16713603-5	2006	We found that SalB, as well as NADPH oxidase inhibitors, DPI or apocynin, and antioxidant NAC, inhibited TNF-alpha-induced MMP-2 mRNA, protein expression, and gelatinolytic activity in HASMCs in a concentration-dependent manner.	salvianolic acid B	14-18	matrix metallopeptidase 2	Homo sapiens	123-128