PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34180140-6	2021	The ATM inhibitor KU55933 could decrease the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF with ACY1215 pretreatment.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	transformation related protein 53, pseudogene	Mus musculus	77-80	
32157166-4	2020	Analysis of isolated tubular epithelia by FACS from bigenic SLC34a1-CreERt2; R26tdTomato proximal tubular-specific reporter mice revealed that KU55933 upregulated p53 and subsequent pro-apoptotic signaling in tubular epithelia of cisplatin-treated mice, leading to marked mitochondrial injury and apoptosis.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	143-150	transformation related protein 53, pseudogene	Mus musculus	163-166	
28780388-3	2018	This suggested an alternative signaling system redundant with ATM kinase for activating p53 in this cell line- one that was altered by KU55933 at these higher concentrations (i.e. mTORC1, DNApk, PI3K).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	135-142	transformation related protein 53, pseudogene	Mus musculus	88-91	
28341201-5	2017	Although KU-55933 inhibited the H2O2- and Dox-induced activation of ATM, it attenuated the toxin-induced phosphorylation of the proteins H2AX and p53 only in the latter model of cell damage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	9-17	transformation related protein 53, pseudogene	Mus musculus	146-149	
28341201-0	2017	The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a gammaH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	25-33	transformation related protein 53, pseudogene	Mus musculus	123-126	
24726884-10	2014	Ku55933, an ATM inhibitor, blocked ATM phosphorylation and ameliorated the phosphorylation of Chk2 and p53, but it increased H2AX phosphorylation and nuclear foci formation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-7	transformation related protein 53, pseudogene	Mus musculus	103-106	
34715501-8	2021	Furthermore, pretreatment with the ATM inhibitor KU55933 could reduce the occurrence of autophagy and mitigate testicular toxicity of MC-LR through inhibiting the activation of the ATM/p53 pathway.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	49-56	transformation related protein 53, pseudogene	Mus musculus	185-188