PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35023460-0	2022	Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	36-43	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	27-32	
35023460-4	2022	OBJECTIVE: In the present study, we investigated the inhibitory effect of KU55933 on ABCG2 in CRC.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	74-81	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	85-90	
35023460-5	2022	METHODS: The cytotoxicity assay and drug accumulation assay were used to examine the inhibitory effect of KU55933 on ABCG2.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	106-113	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	117-122	
35023460-7	2022	The docking assay was performed to predict the binding site and intermolecular interactions between KU55933 and ABCG2.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	100-107	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	112-117	
35023460-8	2022	RESULTS: KU55933 was more potent than the known ABCG2 inhibitor fumitremorgin C to enhance the sensitivity of mitoxantrone and doxorubicin and the intracellular accumulation of mitoxantrone, doxorubicin and rhodamine 123 inside CRC cells with ABCG2 overexpression.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	9-16	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	243-248	
35023460-10	2022	Furthermore, the docking data showed that KU55933 was tightly located in the drug-binding pocket of ABCG2.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	42-49	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	100-105	
35023460-11	2022	CONCLUSION: KU55933 can potently inhibit the activity of ABCG2 in CRC.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	12-19	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	57-62