PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31956937-7 2020 The findings demonstrated that LIQ induced cell cycle arrest and apoptosis via the ROS-mediated MAPK/AKT/NF-kappaB signaling pathway in HepG2 cells, and the LIQ may serve as a potential therapeutic agent for the treatment of human HCC. liquiritin 31-34 mitogen-activated protein kinase 1 Homo sapiens 96-100 31956937-7 2020 The findings demonstrated that LIQ induced cell cycle arrest and apoptosis via the ROS-mediated MAPK/AKT/NF-kappaB signaling pathway in HepG2 cells, and the LIQ may serve as a potential therapeutic agent for the treatment of human HCC. liquiritin 157-160 mitogen-activated protein kinase 1 Homo sapiens 96-100 31956937-0 2020 Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-kappaB signaling pathway. liquiritin 0-10 mitogen-activated protein kinase 1 Homo sapiens 117-121 31956937-5 2020 The flow cytometry and western blot analysis also suggested that LIQ promoted the accumulation of ROS in HepG2 cells and up-regulated the phosphorylation expression levels of p38 kinase, c-Jun N-terminal kinase (JNK), and inhibitor of NF-kappaB (IkappaB-alpha); the phosphorylation levels of extracellular signal-regulated kinase (ERK), protein kinase B (AKT), signal transducer activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-kappaB) were down-regulated. liquiritin 65-68 mitogen-activated protein kinase 1 Homo sapiens 292-329 31234488-0 2019 Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways. liquiritin 0-10 mitogen-activated protein kinase 1 Homo sapiens 70-73 31956937-5 2020 The flow cytometry and western blot analysis also suggested that LIQ promoted the accumulation of ROS in HepG2 cells and up-regulated the phosphorylation expression levels of p38 kinase, c-Jun N-terminal kinase (JNK), and inhibitor of NF-kappaB (IkappaB-alpha); the phosphorylation levels of extracellular signal-regulated kinase (ERK), protein kinase B (AKT), signal transducer activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-kappaB) were down-regulated. liquiritin 65-68 mitogen-activated protein kinase 1 Homo sapiens 331-334 31234488-12 2019 Furthermore, LQ- or LQG-mediated melanin synthesis was partially blocked by p38 inhibitor (SB203580) and protein kinase A (PKA) inhibitor (H-89); however, ERK kinase (MEK) inhibitor (U0126) and phosphatidylinositol-3-kinase (PI3K) inhibitor (LY294002) had no effect. liquiritin 13-15 mitogen-activated protein kinase 1 Homo sapiens 76-79