PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35592411-12	2022	Supporting the central involvement of the cAMP/PKA/LKB1/AMPKalpha2 signaling pathway in the cardioprotective effects of LQ, inhibition of Ang II-induced hypertrophy and induction of LKB1 and AMPKalpha phosphorylation were no longer observed after inhibiting PKA activity.	liquiritin	120-122	angiotensinogen	Rattus norvegicus	138-144	
35592411-13	2022	Conclusion: This study revealed that LQ alleviates pressure overload-induced cardiac hypertrophy in vivo and inhibits Ang II-induced cardiomyocyte hypertrophy in vitro via activating cAMP/PKA/LKB1/AMPKalpha2 signaling.	liquiritin	37-39	angiotensinogen	Rattus norvegicus	118-124	
35341136-0	2022	Liquiritin Attenuates Angiotensin II-Induced Cardiomyocyte Hypertrophy via ATE1/TAK1-JNK1/2 Pathway.	liquiritin	0-10	angiotensinogen	Rattus norvegicus	22-36	
35341136-1	2022	Objective: To investigate the protective effect and mechanism of liquiritin (LIQ) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II).	liquiritin	65-75	angiotensinogen	Rattus norvegicus	122-136	
35341136-1	2022	Objective: To investigate the protective effect and mechanism of liquiritin (LIQ) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II).	liquiritin	65-75	angiotensinogen	Rattus norvegicus	138-144	
35341136-1	2022	Objective: To investigate the protective effect and mechanism of liquiritin (LIQ) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II).	liquiritin	77-80	angiotensinogen	Rattus norvegicus	122-136	
35341136-8	2022	The protective effect of LIQ was best observed at 30 muM after Ang II treatment.	liquiritin	25-28	angiotensinogen	Rattus norvegicus	63-69	
35341136-10	2022	On the other hand, Western blotting results showed that Ang II increased the ATE1 protein levels and TAK1 and JNK1/2 phosphorylation, which were significantly alleviated after LIQ treatment.	liquiritin	176-179	angiotensinogen	Rattus norvegicus	56-62	
35341136-12	2022	Conclusion: LIQ can attenuate Ang II-induced cardiomyocyte hypertrophy by regulating the ATE1/TAK1-JNK1/2 pathway.	liquiritin	12-15	angiotensinogen	Rattus norvegicus	30-36