PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31956937-0	2020	Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-kappaB signaling pathway.	liquiritin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	126-135	
34731782-11	2021	Liquiritin attenuated the LPS-aroused NF-kappaB and JNK pathways activation in HaCaT cells.	liquiritin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	38-47	
34731782-17	2021	Liquiritin reduced LPS-aroused HaCaT cell inflammatory damage might be implemented via raising miR-31 expression, lowering MyD88 expression, and repressing NF-kappaB and JNK pathways.	liquiritin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	156-165	
31956937-5	2020	The flow cytometry and western blot analysis also suggested that LIQ promoted the accumulation of ROS in HepG2 cells and up-regulated the phosphorylation expression levels of p38 kinase, c-Jun N-terminal kinase (JNK), and inhibitor of NF-kappaB (IkappaB-alpha); the phosphorylation levels of extracellular signal-regulated kinase (ERK), protein kinase B (AKT), signal transducer activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-kappaB) were down-regulated.	liquiritin	65-68	nuclear factor kappa B subunit 1	Homo sapiens	235-244	
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	liquiritin	368-378	nuclear factor kappa B subunit 1	Homo sapiens	162-171	
31956937-5	2020	The flow cytometry and western blot analysis also suggested that LIQ promoted the accumulation of ROS in HepG2 cells and up-regulated the phosphorylation expression levels of p38 kinase, c-Jun N-terminal kinase (JNK), and inhibitor of NF-kappaB (IkappaB-alpha); the phosphorylation levels of extracellular signal-regulated kinase (ERK), protein kinase B (AKT), signal transducer activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-kappaB) were down-regulated.	liquiritin	65-68	nuclear factor kappa B subunit 1	Homo sapiens	421-443	
31956937-5	2020	The flow cytometry and western blot analysis also suggested that LIQ promoted the accumulation of ROS in HepG2 cells and up-regulated the phosphorylation expression levels of p38 kinase, c-Jun N-terminal kinase (JNK), and inhibitor of NF-kappaB (IkappaB-alpha); the phosphorylation levels of extracellular signal-regulated kinase (ERK), protein kinase B (AKT), signal transducer activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-kappaB) were down-regulated.	liquiritin	65-68	nuclear factor kappa B subunit 1	Homo sapiens	445-454	
31956937-7	2020	The findings demonstrated that LIQ induced cell cycle arrest and apoptosis via the ROS-mediated MAPK/AKT/NF-kappaB signaling pathway in HepG2 cells, and the LIQ may serve as a potential therapeutic agent for the treatment of human HCC.	liquiritin	31-34	nuclear factor kappa B subunit 1	Homo sapiens	105-114	
29901082-0	2018	Liquiritin suppresses UVB-induced skin injury through prevention of inflammation, oxidative stress and apoptosis through the TLR4/MyD88/NF-kappaB and MAPK/caspase signaling pathways.	liquiritin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	136-145	
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	liquiritin	73-83	nuclear factor kappa B subunit 1	Homo sapiens	162-171	
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	liquiritin	73-83	nuclear factor kappa B subunit 1	Homo sapiens	400-409	
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	liquiritin	368-378	nuclear factor kappa B subunit 1	Homo sapiens	162-171