PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21220478-8 2011 The relative levels of Bcl-x(L) and Mcl-1 correlate with the extent of synergy, suggesting that cancers with elevated levels of Bcl-x(L) will be relatively resistant to taxane-based therapy but could benefit from the addition of navitoclax to taxane treatment. taxane 169-175 BCL2 like 1 Homo sapiens 23-31 22302098-5 2012 We evaluated Bcl-x(L) levels in ovarian cancer tumor tissue from 40 patients (20 taxane responsive and 20 with poor response to taxane) and found that patients with high Bcl-x(L) were less sensitive to taxane treatment (10 of 12) Bcl-x(L) positive patients, P = 0.014). taxane 81-87 BCL2 like 1 Homo sapiens 13-21 22302098-5 2012 We evaluated Bcl-x(L) levels in ovarian cancer tumor tissue from 40 patients (20 taxane responsive and 20 with poor response to taxane) and found that patients with high Bcl-x(L) were less sensitive to taxane treatment (10 of 12) Bcl-x(L) positive patients, P = 0.014). taxane 128-134 BCL2 like 1 Homo sapiens 13-21 22302098-5 2012 We evaluated Bcl-x(L) levels in ovarian cancer tumor tissue from 40 patients (20 taxane responsive and 20 with poor response to taxane) and found that patients with high Bcl-x(L) were less sensitive to taxane treatment (10 of 12) Bcl-x(L) positive patients, P = 0.014). taxane 128-134 BCL2 like 1 Homo sapiens 13-21 22302098-6 2012 These data support the use of navitoclax in combination with taxane-based therapy in ovarian cancer patients with high levels of Bcl-x(L). taxane 61-67 BCL2 like 1 Homo sapiens 129-137 21220478-8 2011 The relative levels of Bcl-x(L) and Mcl-1 correlate with the extent of synergy, suggesting that cancers with elevated levels of Bcl-x(L) will be relatively resistant to taxane-based therapy but could benefit from the addition of navitoclax to taxane treatment. taxane 169-175 BCL2 like 1 Homo sapiens 128-136 21220478-8 2011 The relative levels of Bcl-x(L) and Mcl-1 correlate with the extent of synergy, suggesting that cancers with elevated levels of Bcl-x(L) will be relatively resistant to taxane-based therapy but could benefit from the addition of navitoclax to taxane treatment. taxane 243-249 BCL2 like 1 Homo sapiens 23-31 21220478-8 2011 The relative levels of Bcl-x(L) and Mcl-1 correlate with the extent of synergy, suggesting that cancers with elevated levels of Bcl-x(L) will be relatively resistant to taxane-based therapy but could benefit from the addition of navitoclax to taxane treatment. taxane 243-249 BCL2 like 1 Homo sapiens 128-136 21220478-10 2011 CONCLUSIONS: The addition of navitoclax to taxane-based chemotherapy in NSCLC has the potential to increase efficacy, particularly in patients whose tumors express high levels of Bcl-x(L). taxane 43-49 BCL2 like 1 Homo sapiens 179-187