PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31618900-0 2019 Glucosamine Enhances TRAIL-Induced Apoptosis in the Prostate Cancer Cell Line DU145. Glucosamine 0-11 TNF superfamily member 10 Homo sapiens 21-26 31618900-3 2019 Methods: Immunoblotting, flow cytometry, confocal microscopy, qPCR and caspase 8 activity assays were used to investigate whether glucosamine (GlcN) can sensitize cancer cells to TRAIL thereby enhancing apoptosis and potentially improving clinical response. Glucosamine 130-141 TNF superfamily member 10 Homo sapiens 179-184 31618900-3 2019 Methods: Immunoblotting, flow cytometry, confocal microscopy, qPCR and caspase 8 activity assays were used to investigate whether glucosamine (GlcN) can sensitize cancer cells to TRAIL thereby enhancing apoptosis and potentially improving clinical response. Glucosamine 143-147 TNF superfamily member 10 Homo sapiens 179-184 31618900-4 2019 Results: GlcN sensitized DU145 cells to TRAIL-induced apoptosis but did not increase death receptor 5 (DR5) cell surface expression. Glucosamine 9-13 TNF superfamily member 10 Homo sapiens 40-45 31618900-7 2019 In addition to the activation of apoptotic pathways, TRAIL-mediated inflammatory responses were attenuated by GlcN pretreatment reducing nuclear NF-kB levels and the expression of downstream target genes IL-6 and IL-8. Glucosamine 110-114 TNF superfamily member 10 Homo sapiens 53-58 31618900-8 2019 Conclusions: GlcN/TRAIL combination could be a promising strategy for treating cancers by overcoming TRAIL resistance and abrogating TRAIL-induced inflammation. Glucosamine 13-17 TNF superfamily member 10 Homo sapiens 101-106 31618900-8 2019 Conclusions: GlcN/TRAIL combination could be a promising strategy for treating cancers by overcoming TRAIL resistance and abrogating TRAIL-induced inflammation. Glucosamine 13-17 TNF superfamily member 10 Homo sapiens 101-106