PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24502806-12	2014	In vitro assays revealed that TMP inhibited NF-kappaB translocation and its downstream production of inflammatory factors, such as TNF-alpha, IL-6 and IL-8, and that ROS production that was induced by LPS in Caco-2 cells.	tetramethylpyrazine	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	151-155	
21637924-0	2011	Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways.	tetramethylpyrazine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	110-123	
21637924-5	2011	The role of TMP in association with IL-8 in the tumor cell migratory process remains unclear.	tetramethylpyrazine	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	36-40	
21637924-6	2011	The purpose of the present study was to determine whether TMP influences the migratory ability of a human ovarian carcinoma cell line (SKOV3) via regulation of IL-8 expression in vitro.	tetramethylpyrazine	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	160-164	
21637924-7	2011	Cell counts showed that treatment of SKOV3 with TMP (25-100 microg/ml) for 24 h did not decrease cell numbers, while an effect of TMP on the down-regulation of the expression of IL-8 was observed.	tetramethylpyrazine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	178-182	
21637924-8	2011	In addition, migration of SKOV3 cells was suppressed after treatment with TMP (25-100 microg/ml) for 24 h. Therefore, expression of IL-8 by SKOV3 cells correlates with their metastatic potential.	tetramethylpyrazine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	132-136	
21637924-12	2011	Our data suggest that TMP may inhibit tumor cell invasion and migration, at least in part, through its down-regulation of IL-8 expression.	tetramethylpyrazine	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	122-126	
19540326-0	2009	Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappaB signaling pathways.	tetramethylpyrazine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	31-44	
19540326-1	2009	AIM OF THE STUDY: To determine the anti-inflammatory effects of Tetramethylpyrazine (TMP) and to investigate the inhibitory effect of TMP on IL-8 production in human umbilical vein endothelial cells (HUVECs) induced by LPS might be mediated by inhibiting p38, ERK and NF-kappaB signaling pathways.	tetramethylpyrazine	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	141-145	
19540326-6	2009	RESULTS: TMP inhibits LPS-induced IL-8 production in HUVECs at both the protein and mRNA levels, suggesting that TMP has an antiinflammatory effect on endothelial cells.	tetramethylpyrazine	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	34-38	
19540326-6	2009	RESULTS: TMP inhibits LPS-induced IL-8 production in HUVECs at both the protein and mRNA levels, suggesting that TMP has an antiinflammatory effect on endothelial cells.	tetramethylpyrazine	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	34-38	
19540326-10	2009	CONCLUSIONS: The inhibitory effect of TMP on the LPS-induced IL-8 production is mediated by the NF-kappaB-dependent pathway, and TMP also separately affects the ERK and p38 MAPK pathway.	tetramethylpyrazine	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	61-65