PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34774545-5	2022	Chemical inhibition and reaction phenotyping assays suggested that human carboxylesterase 1 (hCES1A) played a predominant role in remdesivir hydrolysis, while cathepsin A (CTSA), acetylcholinesterase (AchE) and butyrylcholinesterase (BchE) contributed to a lesser extent.	remdesivir	130-140	carboxylesterase 1	Homo sapiens	73-91	
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	remdesivir	125-128	carboxylesterase 1	Homo sapiens	40-58	
34918945-3	2021	However, following intravenous administration, RDV metabolizes majorly by human liver carboxylesterase 1 (CES1) and marginally by the CYP3A4 enzyme in merely less than an hour.	remdesivir	47-50	carboxylesterase 1	Homo sapiens	80-104	
34918945-3	2021	However, following intravenous administration, RDV metabolizes majorly by human liver carboxylesterase 1 (CES1) and marginally by the CYP3A4 enzyme in merely less than an hour.	remdesivir	47-50	carboxylesterase 1	Homo sapiens	106-110	
34918945-6	2021	Objective: Considering the major CES1-mediated metabolism of RDV on systemic administration, we intend to explore the remarkable CES1 plus CYP3A4 inhibitory activity of cannabidiol (CBD) against in vitro microsomal metabolism of RDV to indicate its therapeutic potential as an adjuvant to RDV in the treatment and management of COVID-19.	remdesivir	61-64	carboxylesterase 1	Homo sapiens	33-37	
34918945-6	2021	Objective: Considering the major CES1-mediated metabolism of RDV on systemic administration, we intend to explore the remarkable CES1 plus CYP3A4 inhibitory activity of cannabidiol (CBD) against in vitro microsomal metabolism of RDV to indicate its therapeutic potential as an adjuvant to RDV in the treatment and management of COVID-19.	remdesivir	61-64	carboxylesterase 1	Homo sapiens	129-133	
34510834-0	2021	The COVID-19 Medicine Remdesivir Is Therapeutically Activated by Carboxylesterase-1, and Excessive Hydrolysis Increases Cytotoxicity.	remdesivir	22-32	carboxylesterase 1	Homo sapiens	65-83	
34370586-2	2021	titled, "Key Metabolic Enzymes in Remdesivir Activation in Lung Cells," validates the canonical McGuigan enzymes (CES1, CTSA, HINT1) involved in remdesivir"s (RDV"s) bioactivation using bioinformatic and biochemical approaches (1).....	remdesivir	34-44	carboxylesterase 1	Homo sapiens	114-118	
34370586-2	2021	titled, "Key Metabolic Enzymes in Remdesivir Activation in Lung Cells," validates the canonical McGuigan enzymes (CES1, CTSA, HINT1) involved in remdesivir"s (RDV"s) bioactivation using bioinformatic and biochemical approaches (1).....	remdesivir	145-155	carboxylesterase 1	Homo sapiens	114-118	
34125594-4	2021	Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1).	remdesivir	125-128	carboxylesterase 1	Homo sapiens	60-64