PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21044953-11	2010	Collectively, we conclude that small molecules such as celecoxib induce DR5 expression through activating ERK/RSK signaling and subsequent Elk1 activation and ATF4-dependent CHOP induction.	Celecoxib	55-64	ribosomal protein S6 kinase A3	Homo sapiens	110-113	
21044953-3	2010	The current study has revealed a novel ERK/ribosomal S6 kinase (RSK)-dependent mechanism that regulates DR5 expression primarily using celecoxib as a DR5 inducer.	Celecoxib	135-144	ribosomal protein S6 kinase A3	Homo sapiens	64-67	
21044953-6	2010	Because Elk1 is an ERK-regulated protein, we accordingly found that celecoxib increased the levels of phosphorylated ERK1/2, RSK2, and Elk1.	Celecoxib	68-77	ribosomal protein S6 kinase A3	Homo sapiens	125-129	
21044953-7	2010	Inhibition of either ERK signaling with a MEK inhibitor or ERK1/2 siRNA, or RSK2 signaling with an RSK2 inhibitor or RSK2 siRNA abrogated DR5 up-regulation by celecoxib as well as other agents.	Celecoxib	159-168	ribosomal protein S6 kinase A3	Homo sapiens	76-80	
21044953-7	2010	Inhibition of either ERK signaling with a MEK inhibitor or ERK1/2 siRNA, or RSK2 signaling with an RSK2 inhibitor or RSK2 siRNA abrogated DR5 up-regulation by celecoxib as well as other agents.	Celecoxib	159-168	ribosomal protein S6 kinase A3	Homo sapiens	99-103	
21044953-7	2010	Inhibition of either ERK signaling with a MEK inhibitor or ERK1/2 siRNA, or RSK2 signaling with an RSK2 inhibitor or RSK2 siRNA abrogated DR5 up-regulation by celecoxib as well as other agents.	Celecoxib	159-168	ribosomal protein S6 kinase A3	Homo sapiens	99-103